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公开(公告)号：US06239259B1
公开(公告)日：2001-05-29
申请号：US09171025
申请日：1998-12-28
IPC分类号： C07K1600
CPC分类号： C07K16/468 , A61K38/00 , C07K16/00 , C07K2319/00 , Y10S530/808
摘要： A multivalent antigen-binding protein comprises a first polypeptide comprising, in series, three or more variable domains of an antibody heavy chain and a second polypeptide comprising, in series, three of more variable domains of an antibody light chain, said first and second polypeptides being linked by association of the respective heavy chain and light chain variable domains, each associated variable domain pair forming an antigen binding site. Methods for their production and uses thereof, in particular for therapeutic and diagnostic applications, are disclosed.
摘要翻译： 多价抗原结合蛋白包含第一多肽，其序列包含抗体重链的三个或更多个可变结构域和第二多肽，其包含串联的三个抗体轻链的多个可变结构域，所述第一和第二多肽 通过各重链和轻链可变结构域的关联连接，每个相关的可变结构域对形成抗原结合位点。 公开了其生产方法及其用途，特别是用于治疗和诊断应用。
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公开(公告)号：US5490988A
公开(公告)日：1996-02-13
申请号：US335925
申请日：1994-11-08
IPC分类号： A61K9/06 , A61K8/66 , A61K9/08 , A61K9/20 , A61K38/44 , A61K39/395 , A61K47/48 , A61P1/02 , A61Q11/00 , C07K16/42 , A61K7/16 , A61K39/00
CPC分类号： A61K47/4843 , A61K47/487 , A61K8/66 , A61Q11/00 , C07K16/4283 , A61K2800/94
摘要： An antibody fragment able to bind to a target site is prolonged by an additional peptide. The Therapeutic agent is bound to this peptide or means are provided to bring about such binding. The antibody fragment and possibly also the therapeutic agent are included in a product so that binding to the target site delivers the therapeutic agent to the vicinity. The product may for example be for dental care, such as a toothpaste or mouthwash and the antibody fragment may then bind to a component of dental plaque.
摘要翻译： 能够结合靶位点的抗体片段被另外的肽延长。 治疗剂与该肽结合或提供手段以产生这种结合。 抗体片段和可能的治疗剂包括在产品中，使得与靶位点的结合将治疗剂递送到附近。 该产品可以例如用于牙科保健，例如牙膏或漱口剂，并且抗体片段然后可以结合牙菌斑的组分。
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公开(公告)号：US07034203B1
公开(公告)日：2006-04-25
申请号：US09626377
申请日：1999-01-25
申请人： Arnaud G. Bovy , Hendrikus T. van der Hijden , Stephen G. Hughes , Shelagh R. Muir , Adrianus J. van Tunen , Martine E. Verhoeyen , Cornelis H. de Vos
发明人： Arnaud G. Bovy , Hendrikus T. van der Hijden , Stephen G. Hughes , Shelagh R. Muir , Adrianus J. van Tunen , Martine E. Verhoeyen , Cornelis H. de Vos
CPC分类号： C07K14/415 , A23L19/03 , A23L19/09 , A23L33/105 , C12N15/8243 , C12N15/825
摘要： A method for manipulating the production of flavonoids other than anthocyanins in plants by manipulating gene activity in the flavonoid biosynthetic pathway by expressing two or more genes encoding transcription factors for flavonoid biosynthesis, compositions for use in such a method and tomato plants having altered flavonoid levels are disclosed.
摘要翻译： 通过表达两种以上编码黄酮生物合成转录因子的基因和用于这种方法的组合物以及具有改变的类黄酮水平的番茄植物，通过操作类黄酮生物合成途径中的基因活性来操作植物中除花青素以外的类黄酮的生产方法 披露
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