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1.发明申请SENECA VALLEY VIRUS BASED COMPOSITIONS AND METHODS FOR TREATING DISEASE 有权SENECA VALLEY VIRUS基于组合物和治疗疾病的方法公开(公告)号：US20120034676A1
公开(公告)日：2012-02-09
申请号：US13209124
申请日：2011-08-12
申请人： Paul L. HALLENBECK , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul L. HALLENBECK , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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2.发明授权公开(公告)号：US07638318B2
公开(公告)日：2009-12-29
申请号：US11335891
申请日：2006-01-19
申请人： Paul L. Hallenbeck , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul L. Hallenbeck , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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3.发明授权公开(公告)号：US08753622B2
公开(公告)日：2014-06-17
申请号：US13209124
申请日：2011-08-12
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K35/76 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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4.发明授权公开(公告)号：US08039606B2
公开(公告)日：2011-10-18
申请号：US12576296
申请日：2009-10-09
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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