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1.发明申请SENECA VALLEY VIRUS BASED COMPOSITIONS AND METHODS FOR TREATING DISEASE 有权SENECA VALLEY VIRUS基于组合物和治疗疾病的方法公开(公告)号：US20120034676A1
公开(公告)日：2012-02-09
申请号：US13209124
申请日：2011-08-12
申请人： Paul L. HALLENBECK , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul L. HALLENBECK , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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2.发明授权公开(公告)号：US07638318B2
公开(公告)日：2009-12-29
申请号：US11335891
申请日：2006-01-19
申请人： Paul L. Hallenbeck , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul L. Hallenbeck , Seshidar Reddy Police , Laura M. Hales , Carl M. Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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3.发明授权公开(公告)号：US08753622B2
公开(公告)日：2014-06-17
申请号：US13209124
申请日：2011-08-12
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K35/76 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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4.发明授权公开(公告)号：US08039606B2
公开(公告)日：2011-10-18
申请号：US12576296
申请日：2009-10-09
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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5.发明申请公开(公告)号：US20060159659A1
公开(公告)日：2006-07-20
申请号：US11335891
申请日：2006-01-19
申请人： Paul Hallenbeck , Seshidar Police , Laura Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidar Police , Laura Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K48/00 , C07H21/04 , C12N7/00 , C12N15/86 , C07K14/085
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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公开(公告)号：US20120075191A1
公开(公告)日：2012-03-29
申请号：US13260648
申请日：2010-03-24
申请人： Jingping Yang , Ke Shang , James Rutledge
发明人： Jingping Yang , Ke Shang , James Rutledge
CPC分类号： G06F3/0428
摘要： The present invention provides an optical touch system, applied to an electronic apparatus having at least a physical plane. It comprises: an optical unit set on the physical plane and configured to produce a first optical effect; an image acquisition unit set on the physical plane, at least a part of the optical unit being within an acquisition range of the image acquisition unit, a touch operation area being formed by the image acquisition unit and the optical unit; the image acquisition unit configured to capture an image having a second optical effect which is formed on the first optical effect after an operation body for operating the electronic apparatus enters the touch operation area; a processing unit being connected with the image acquisition unit and configured to determine the range of the operation body in the touch operation area according to the image having the second optical effect. The present invention also provides an optical touch input display apparatus and optical touch input positioning method. The touch system of the present invention is low-cost and highly reliable.
摘要翻译： 本发明提供一种应用于至少具有物理平面的电子设备的光学触摸系统。 它包括：设置在物理平面上并被配置为产生第一光学效应的光学单元; 设置在所述物理平面上的图像获取单元，所述光学单元的至少一部分在所述图像获取单元的获取范围内;触摸操作区域，由所述图像获取单元和所述光学单元形成; 所述图像获取单元被配置为在用于操作所述电子设备的操作体进入所述触摸操作区域之后捕获具有形成在所述第一光学效果上的具有第二光学效果的图像; 处理单元与图像获取单元连接，并且被配置为根据具有第二光学效果的图像来确定触摸操作区域中的操作体的范围。 本发明还提供了一种光学触摸输入显示装置和光学触摸输入定位方法。 本发明的触摸系统是低成本且高度可靠的。
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公开(公告)号：US09040002B2
公开(公告)日：2015-05-26
申请号：US12650247
申请日：2009-12-30
CPC分类号： B01L3/50853 , B01L2200/021 , B01L2200/025 , B01L2200/141 , B01L2300/021 , B01L2300/044 , B01L2300/0829 , B01L2300/123
摘要： Provided is a masking system of masks for use with multiwell plates such as microtiter plates to facilitate sample dispensing and assay accuracy, especially when dispensing more than one solution into the wells. One or more masks, adapted in size to fit snugly over a multiwell plate and the mask formed with openings each aligned with a subset of one or more wells of the plate beneath, aids the user in sample and/or reagent administration. Advantageously, the masks contain registration aids so that proper orientation with respect to the plate below is achieved; the registration aid may be a cut corner, registration peg or mark, or visual marking or stamping.
摘要翻译： 提供了一种掩模系统，用于与多孔板（例如微量滴定板）一起使用以便于样品分配和测定精度，特别是当将多种溶液分配到孔中时。 一个或多个掩模尺寸适合紧贴在多孔板上，并且形成有开口的掩模，每个开口均与板下面的一个或多个孔的子集对齐，帮助用户进行样品和/或试剂管理。 有利地，掩模包含配准助剂，从而实现相对于下面的板的适当取向; 注册援助可以是切角，注册钉或标记，或视觉标记或冲压。
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公开(公告)号：US09626043B2
公开(公告)日：2017-04-18
申请号：US13260648
申请日：2010-03-24
申请人： Jingping Yang , Ke Shang , James Rutledge
发明人： Jingping Yang , Ke Shang , James Rutledge
IPC分类号： G06F3/042
CPC分类号： G06F3/0428
摘要： The present invention provides an optical touch system, applied to an electronic apparatus having at least a physical plane. It comprises: an optical unit set on the physical plane and configured to produce a first optical effect; an image acquisition unit set on the physical plane, at least a part of the optical unit being within an acquisition range of the image acquisition unit, a touch operation area being formed by the image acquisition unit and the optical unit; the image acquisition unit configured to capture an image having a second optical effect which is formed on the first optical effect after an operation body for operating the electronic apparatus enters the touch operation area; a processing unit being connected with the image acquisition unit and configured to determine the range of the operation body in the touch operation area according to the image having the second optical effect. The present invention also provides an optical touch input display apparatus and optical touch input positioning method. The touch system of the present invention is low-cost and highly reliable.
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公开(公告)号：US08597938B2
公开(公告)日：2013-12-03
申请号：US12249791
申请日：2008-10-10
申请人： Jingping Yang , Li Shen
发明人： Jingping Yang , Li Shen
CPC分类号： C12Q1/686 , C12Q2561/113
摘要： Provided are methods and oligonucleotides useful as primers and templates for internal controls designed for use in Real Time Reverse Transcriptase Polymerase Chain Reactions. Use of the present methods and oligonucleotides allows validation of assay parameters and of the results that an assay set.
摘要翻译： 提供的方法和寡核苷酸可用作设计用于实时逆转录酶聚合酶链反应的内部对照的引物和模板。 使用本发明的方法和寡核苷酸允许验证测定参数和测定组的结果。
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