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公开(公告)号：US12029640B2
公开(公告)日：2024-07-09
申请号：US16212874
申请日：2018-12-07
CPC分类号： A61F2/0805 , A61B17/8811 , A61B17/8836 , A61L24/06 , A61L27/18 , A61B2017/005 , A61B2017/00734 , A61F2002/0817 , A61F2002/0852 , A61F2002/0888 , A61F2210/0085 , A61L2400/06
摘要： An implant injection system and method for introducing a bone implant material into a patient's bone to serve as an anchor or to fill a void in the bone. The system and method provide a quantity of meltable material which is melted in situ so that the melted material can flow and diffuse into, and be anchored to, the cancellous bone portion beneath the cortical bone layer. The flowing of the bone implant material can be accomplished by a heater located at the distal end of the implant injection system. The implant material may be provided in multiple layers with an inner layer having a lower flowing temperature than the outer layers. There can also be a looped suture that passes though the meltable material, with the free ends of the suture extending outwardly to be tied to soft tissue to affix the soft tissue to the bone.
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公开(公告)号：US20210015529A1
公开(公告)日：2021-01-21
申请号：US16981563
申请日：2019-03-18
摘要： This invention comprises a novel approach for the refixation of a loosened implant to bone, wherein the novel approach comprises providing access to a boundary region between the implant and the bone; removing abnormal interface tissue, wear debris and/or bone cement debris from the boundary region; and inserting bone fixation material into the boundary region so that the bone fixation material engages the implant and the bone and thereby effects refixation of the loosened implant to the bone.
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公开(公告)号：US20190175329A1
公开(公告)日：2019-06-13
申请号：US16212874
申请日：2018-12-07
摘要： An implant injection system that facilitates the introduction of a bone implant material into the cancellous bone portion of a patient's bone to serve as an anchor or to fill a void in the bone. The implant injection system and method provide a quantity of meltable material which is melted in situ so that the melted material can flow and diffuse into, and be anchored to, the cancellous bone portion beneath the cortical bone layer. The flowing of the bone implant material can be accomplished by an electrical resistance heater or other heater located at the distal end of the implant injection system. The implant material may be provided in multiple layers with an inner layer having a lower flowing temperature than the outer layers. There can also be a looped suture that passes though the meltable material, with the free ends of the suture extending outwardly to be tied to soft tissue to affix the soft tissue to the bone.
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公开(公告)号：US20100167941A1
公开(公告)日：2010-07-01
申请号：US12462921
申请日：2009-08-11
申请人： Nigel G. Skinner , Paul Fenton , George A. Adaniya
发明人： Nigel G. Skinner , Paul Fenton , George A. Adaniya
CPC分类号： G01N33/54346 , C12Q1/6827 , C12Q1/6874 , G01N33/54373 , Y10T428/2982 , Y10T436/13 , C12Q2565/501 , C12Q2563/185 , C12Q2563/149
摘要： The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a differential electromagnetic radiation (either different intensity, different frequency or no radiation), and wherein the arrangement of said portions of the surface defines a spatially distributed code for identifying the particle. The invention also provides method of manufacturing a particle having an identifying code comprising providing a particle with a functionalized surface which comprises functional binding moieties and selectively removing a plurality of the functional binding moieties from the surface to create a pattern of functionalized and differentially-functionalized zones on the surface. Various liquid-based assay methods employing the particle of the invention and a kit comprising the particle of the invention are also disclosed.
摘要翻译： 本发明提供一种包括表面的颗粒，其中表面的一部分能够发射电磁辐射，并且表面的另一部分能够发射差分电磁辐射（不同强度，不同频率或不辐射），并且其中 表面的所述部分的布置限定了用于识别颗粒的空间分布的代码。 本发明还提供了制造具有识别代码的颗粒的方法，该方法包括向颗粒提供包含功能性结合部分的官能化表面，并从表面选择性地除去多个功能结合部分以产生官能化和差异功能化区域的图案 在表面上。 还公开了使用本发明颗粒的各种液体测定方法和包含本发明颗粒的试剂盒。
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5.发明授权Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns 失效基于颗粒的测定，其在空间分布的特征图案中与靶特异性结合公开(公告)号：US07572642B2
公开(公告)日：2009-08-11
申请号：US10125102
申请日：2002-04-17
申请人： Nigel G. Skinner , Paul Fenton , George A. Adaniya
发明人： Nigel G. Skinner , Paul Fenton , George A. Adaniya
IPC分类号： G01N33/543
CPC分类号： G01N33/54346 , C12Q1/6827 , C12Q1/6874 , G01N33/54373 , Y10T428/2982 , Y10T436/13 , C12Q2565/501 , C12Q2563/185 , C12Q2563/149
摘要： The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a differential electromagnetic radiation (either different intensity, different frequency or no radiation), and wherein the arrangement of said portions of the surface defines a spatially distributed code for identifying the particle. The invention also provides method of manufacturing a particle having an identifying code comprising providing a particle with a functionalized surface which comprises functional binding moieties and selectively removing a plurality of the functional binding moieties from the surface to create a pattern of functionalized and differentially-functionalized zones on the surface. Various liquid-based assay methods employing the particle of the invention and a kit comprising the particle of the invention are also disclosed.
摘要翻译： 本发明提供一种包括表面的颗粒，其中表面的一部分能够发射电磁辐射，并且表面的另一部分能够发射差分电磁辐射（不同强度，不同频率或不辐射），并且其中 表面的所述部分的布置限定了用于识别颗粒的空间分布的代码。 本发明还提供了制造具有识别代码的颗粒的方法，该方法包括向颗粒提供包含功能性结合部分的官能化表面，并从表面选择性地除去多个功能结合部分以产生官能化和差异功能化区域的图案 在表面上。 还公开了使用本发明颗粒的各种液体测定方法和包含本发明颗粒的试剂盒。
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