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    HAZARDOUS AGENT INJECTION SYSTEM
    3.
    发明申请
    HAZARDOUS AGENT INJECTION SYSTEM 有权
    危险代理注射系统

    公开(公告)号：US20130030367A1

    公开(公告)日：2013-01-31

    申请号：US13607659

    申请日：2012-09-07

    申请人： Paul Wotton ,  Peter L. Sadowski ,  John William Hayes

    发明人： Paul Wotton ,  Peter L. Sadowski ,  John William Hayes

    IPC分类号： A61M5/20

    CPC分类号： A61M5/30 ,  A61K9/0019 ,  A61K9/0087 ,  A61K31/519 ,  A61K31/568 ,  A61M5/178 ,  A61M5/2033 ,  A61M5/3202 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2005/3247

    摘要： A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

    摘要翻译： 一种危险剂注射系统，包括约0.02ml至约4.0ml浓度为约7.5mg / ml至约150mg / ml的甲氨蝶呤; 一种针辅助喷射喷射器，其包括容纳甲氨蝶呤的容器; 与所述容器相关联的注射出口构件; 注射辅助针，其联接到所述注射出口构件; 与容器相关联的击发机构; 与发射机构相关联的能量源; 以及与所述击发机构相关联的触发机构，其中所述针辅助喷射器被配置为从所述注射出口构件喷射所述甲氨蝶呤，使得针刺喷射的甲氨蝶呤的C max，T max和生物利用度落在约80％和 用手动注射器输送的甲氨蝶呤的Cmax，Tmax和生物利用度的约125％。

    Hazardous agent injection system
    4.
    发明授权
    Hazardous agent injection system 有权
    危险剂注射系统

    公开(公告)号：US08480631B2

    公开(公告)日：2013-07-09

    申请号：US13607659

    申请日：2012-09-07

    申请人： Paul Wotton ,  Peter L. Sadowsky ,  John William Hayes

    发明人： Paul Wotton ,  Peter L. Sadowsky ,  John William Hayes

    IPC分类号： A61M5/00 ,  A61M5/315

    CPC分类号： A61M5/30 ,  A61K9/0019 ,  A61K9/0087 ,  A61K31/519 ,  A61K31/568 ,  A61M5/178 ,  A61M5/2033 ,  A61M5/3202 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2005/3247

    摘要： A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

    摘要翻译： 一种危险剂注射系统，包括约0.02ml至约4.0ml浓度为约7.5mg / ml至约150mg / ml的甲氨蝶呤; 一种针辅助喷射喷射器，其包括容纳甲氨蝶呤的容器; 与所述容器相关联的注射出口构件; 注射辅助针，其联接到所述注射出口构件; 与容器相关联的击发机构; 与发射机构相关联的能量源; 以及与所述击发机构相关联的触发机构，其中所述针辅助喷射器被配置为从所述注射出口构件喷射所述甲氨蝶呤，使得针刺喷射的甲氨蝶呤的C max，T max和生物利用度落在约80％和 用手动注射器输送的甲氨蝶呤的Cmax，Tmax和生物利用度的约125％。