-
公开(公告)号:US20060199764A1
公开(公告)日:2006-09-07
申请号:US11361565
申请日:2006-02-23
申请人: Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
摘要: The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where R1, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
摘要翻译: 本发明提供了下式的成纤维细胞生长因子肝素结合类似物:其中R 1,R 2,R 3,R SUB > 4,R 5,X,Y和Z如上所定义,药物组合物,包衣组合物和包括上述配方的成纤维细胞生长因子肝素结合类似物的医疗装置和方法 及其用途。
-
公开(公告)号:US20050196425A1
公开(公告)日:2005-09-08
申请号:US11064039
申请日:2005-02-22
申请人: Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
CPC分类号: C07K14/4705 , A61K31/727 , A61K38/00 , A61K38/1875 , A61K47/64 , A61L27/34 , C07H21/04 , C07K14/475 , C07K14/503 , C07K14/51 , C07K2319/00 , C08L89/00
摘要: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译: 式I和式II的本发明的化合物在说明书中公开,其中所述化合物是骨形态发生蛋白活性的调节剂。 化合物是具有非生长因子肝素结合区的合成肽,接头和与骨形态发生蛋白的受体特异性结合的序列。 公开了本发明化合物在治疗骨损伤,退行性关节疾病和增强骨形成中的用途。
-
公开(公告)号:US08227411B2
公开(公告)日:2012-07-24
申请号:US11361565
申请日:2006-02-23
申请人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
摘要: The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where R1, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
摘要翻译: 本发明提供下式的成纤维细胞生长因子肝素结合类似物:其中R1,R2,R3,R4,R5,X,Y和Z如上所定义,药物组合物,包衣组合物和包括成纤维细胞生长因子肝素 - 上述式的类似物及其方法和用途。
-
公开(公告)号:US08101570B2
公开(公告)日:2012-01-24
申请号:US12786256
申请日:2010-05-24
申请人: Kazuyuki Takahashi , Paul O. Zamora , Louis A. Pena , Xinhua Lin
发明人: Kazuyuki Takahashi , Paul O. Zamora , Louis A. Pena , Xinhua Lin
IPC分类号: A61K38/16
CPC分类号: C07K14/522 , A61K38/00 , C07K14/49 , C07K14/51
摘要: A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
摘要翻译: 具有从单个氨基酸残基分支的两个基本相似的序列(同二聚体序列)的肝素结合生长因子(HBGF)类似物,其中序列是与肝素结合生长因子受体(HBGFR)结合的特定HBGF的类似物, 或者可以结合HBGFR而不是任何特定HBGF的类似物。 同型二聚体序列可以衍生自HBGF的任何部分。 合成的HBGF类似物可以是激素,细胞因子,淋巴因子,趋化因子或白细胞介素的类似物,并且可以结合任何HBGFR。 还提供了用于医疗装置,药物组合物及其使用方法的制剂。
-
公开(公告)号:US07482427B2
公开(公告)日:2009-01-27
申请号:US11064039
申请日:2005-02-22
申请人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
CPC分类号: C07K14/4705 , A61K31/727 , A61K38/00 , A61K38/1875 , A61K47/64 , A61L27/34 , C07H21/04 , C07K14/475 , C07K14/503 , C07K14/51 , C07K2319/00 , C08L89/00
摘要: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译: 式I和式II的本发明的化合物在说明书中公开,其中所述化合物是骨形态发生蛋白活性的调节剂。 化合物是具有非生长因子肝素结合区的合成肽,接头和与骨形态发生蛋白的受体特异性结合的序列。 公开了本发明化合物在治疗骨损伤,退行性关节疾病和增强骨形成中的用途。
-
公开(公告)号:US20100298218A1
公开(公告)日:2010-11-25
申请号:US12786256
申请日:2010-05-24
申请人: Kazuyuki Takahashi , Paul O. Zamora , Louis A. Pena , Xinhua Lin
发明人: Kazuyuki Takahashi , Paul O. Zamora , Louis A. Pena , Xinhua Lin
IPC分类号: A61K38/18 , C07K14/475 , A61P35/00
CPC分类号: C07K14/522 , A61K38/00 , C07K14/49 , C07K14/51
摘要: A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
摘要翻译: 具有从单个氨基酸残基分支的两个基本相似的序列(同二聚体序列)的肝素结合生长因子(HBGF)类似物,其中序列是与肝素结合生长因子受体(HBGFR)结合的特定HBGF的类似物, 或者可以结合HBGFR而不是任何特定HBGF的类似物。 同型二聚体序列可以衍生自HBGF的任何部分。 合成的HBGF类似物可以是激素,细胞因子,淋巴因子,趋化因子或白细胞介素的类似物,并且可以结合任何HBGFR。 还提供了用于医疗装置,药物组合物及其使用方法的制剂。
-
7.
公开(公告)号:US07528105B1
公开(公告)日:2009-05-05
申请号:US11055428
申请日:2005-02-10
申请人: Louis A. Pena , Paul O. Zamora , Xinhua Lin , Kazuyuki Takahashi
发明人: Louis A. Pena , Paul O. Zamora , Xinhua Lin , Kazuyuki Takahashi
IPC分类号: A61K38/16 , C07K14/475
CPC分类号: C07K14/475 , A61K38/00
摘要: The invention provides synthetic heparin-binding growth factor analogs having at least two different peptide growth factor analog chains, or alternatively two groups of two different peptide chains branched from branch moieties including trifunctional amino acid residues, the two groups separated by a first linker of from 3 to about 20 atoms, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
摘要翻译: 本发明提供具有至少两种不同肽生长因子类似物的合成的肝素结合生长因子类似物,或者另外两组由分支部分分支的两个不同的肽链,包括三官能氨基酸残基,两组由第一接头 3至约20个原子,所述肽链或链结合肝素结合生长因子受体并且通过第二接头(其可以是疏水性第二接头)共价结合于包含肝素结合结构域的非信号肽。 合成的肝素结合生长因子类似物可用作药物,可溶性生物制剂或作为医疗器械的表面涂层。
-
公开(公告)号:US20150353615A9
公开(公告)日:2015-12-10
申请号:US12023801
申请日:2008-01-31
申请人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
IPC分类号: C07K14/47 , C07K14/475 , A61K38/18 , A61K38/17 , A61P19/08
CPC分类号: C07K14/4705 , A61K38/00 , A61K38/1709 , A61K38/1875 , A61L27/34 , C07H21/04 , C07K14/503 , C07K2319/00 , C08L89/00
摘要: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译: 式I和式II的本发明的化合物在说明书中公开,其中所述化合物是骨形态发生蛋白活性的调节剂。 化合物是具有非生长因子肝素结合区的合成肽,接头和与骨形态发生蛋白的受体特异性结合的序列。 公开了本发明化合物在治疗骨损伤,退行性关节疾病和增强骨形成中的用途。
-
公开(公告)号:US20080166392A1
公开(公告)日:2008-07-10
申请号:US12023801
申请日:2008-01-31
申请人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
发明人: Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
IPC分类号: A61L27/54 , A61K38/17 , A61P19/08 , C07K14/475
CPC分类号: C07K14/4705 , A61K38/00 , A61K38/1709 , A61K38/1875 , A61L27/34 , C07H21/04 , C07K14/503 , C07K2319/00 , C08L89/00
摘要: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译: 式I和式II的本发明的化合物在说明书中公开,其中所述化合物是骨形态发生蛋白活性的调节剂。 化合物是具有非生长因子肝素结合区的合成肽,接头和与骨形态发生蛋白的受体特异性结合的序列。 公开了本发明化合物在治疗骨损伤,退行性关节疾病和增强骨形成中的用途。
-
公开(公告)号:US07820172B1
公开(公告)日:2010-10-26
申请号:US11757242
申请日:2007-06-01
申请人: Paul O. Zamora , Kazuyuki Takahashi , Xinhua Lin
发明人: Paul O. Zamora , Kazuyuki Takahashi , Xinhua Lin
摘要: Multi-domain peptides including a heparin-binding peptide sequence covalently linked to a linker sequence, which linker sequence is covalently linked to a trifunctional amino acid residue forming a branch with two arms, with substantially similar (homodimeric) cellular attachment peptide sequences covalently linked, directly or through an intermediate, to each branch arm, where the sequences are cell binding analogs of or derived from laminin or a portion of laminin. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
摘要翻译: 多结构域肽包括与接头序列共价连接的肝素结合肽序列,该接头序列共价连接到三官能氨基酸残基,其形成具有两个臂的分支,基本上相似(同二聚体)细胞连接肽序列共价连接, 直接或通过中间体,到每个分支臂,其中序列是层粘连蛋白或层粘连蛋白的一部分的细胞结合类似物或衍生自层粘连蛋白。 还提供了用于医疗装置,药物组合物及其使用方法的制剂。
-
-
-
-
-
-
-
-
-