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公开(公告)号：US20100035836A1
公开(公告)日：2010-02-11
申请号：US12496311
申请日：2009-07-01
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译： 本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。
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公开(公告)号：US20130018013A1
公开(公告)日：2013-01-17
申请号：US13607472
申请日：2012-09-07
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A61K31/706 , A61P31/14 , C07H19/23
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译： 本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。
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公开(公告)号：US08119607B2
公开(公告)日：2012-02-21
申请号：US12496311
申请日：2009-07-01
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Jahangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译： 本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。
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公开(公告)号：US08501699B2
公开(公告)日：2013-08-06
申请号：US13607472
申请日：2012-09-07
申请人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Hangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Alistair George Draffan , Michael Harding , Richard Hufton , Saba Hangiri , Michael John Lilly , Edward Tyndall , Jianmin Duan , Richard Bethell , George Kukolj
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译： 本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。
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公开(公告)号：US20120122811A1
公开(公告)日：2012-05-17
申请号：US13348429
申请日：2012-01-11
申请人： Paula Francom , Barbara Frey , Silas Bond , Jianmin Duan , Richard Bethell , George Kukolj
发明人： Paula Francom , Barbara Frey , Silas Bond , Jianmin Duan , Richard Bethell , George Kukolj
IPC分类号： A61K31/706 , C12N5/071 , A61P31/16 , C07H19/23
CPC分类号： C07H19/04
摘要： The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
摘要翻译： 本公开涉及用于治疗和预防感染性和增殖性疾病（包括微生物感染和癌症）的双环核苷和核苷酸的制备方法和制备方法。
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公开(公告)号：US08802840B2
公开(公告)日：2014-08-12
申请号：US11908019
申请日：2006-03-08
申请人： Paula Francom , Roland Henry Nearn , Alistair George Draffan , John Nicholas Lambert , Silas Bond
发明人： Paula Francom , Roland Henry Nearn , Alistair George Draffan , John Nicholas Lambert , Silas Bond
IPC分类号： A61K31/7068 , C07H19/23 , A61K38/21
CPC分类号： C07H19/22 , A61K31/706 , C07H19/23
摘要： The invention relates to the use of bicyclic nucleosides and nucleotides based on formula (II) for the treatment of infectious diseases, and in particular, viral infections.
摘要翻译： 本发明涉及基于式（II）的双环核苷和核苷酸用于治疗感染性疾病，特别是病毒感染的用途。
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公开(公告)号：US20090004138A1
公开(公告)日：2009-01-01
申请号：US11908019
申请日：2006-03-08
申请人： Paula Francom , Roland Henry Nearn , Alistair George Draffan , John Nicholas Lambert , Silas Bond
发明人： Paula Francom , Roland Henry Nearn , Alistair George Draffan , John Nicholas Lambert , Silas Bond
IPC分类号： A61K31/7068 , C07H19/23 , A61P31/14 , A61K38/21
CPC分类号： C07H19/22 , A61K31/706 , C07H19/23
摘要： The invention relates to the use of bicyclic nucleosides and nucleotides based on formula (II) for the treatment of infectious diseases, and in particular, viral infections.
摘要翻译： 本发明涉及基于式（II）的双环核苷和核苷酸用于治疗感染性疾病，特别是病毒感染的用途。
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8.发明授权公开(公告)号：US08598194B2
公开(公告)日：2013-12-03
申请号：US12443177
申请日：2007-09-26
申请人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Penelope Anne Mayes
发明人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Penelope Anne Mayes
CPC分类号： A61K39/42 , A61K31/437 , A61K31/4375 , A61K31/501 , A61K31/7056 , C07D471/04 , C07D471/14
摘要： The present invention relates to polycyclic antiviral compounds, and salts thereof, methods for their preparation and compositions containing them, and the use of the compounds and composition in the treatment of viral infections.
摘要翻译： 本发明涉及多环抗病毒化合物及其盐，其制备方法和含有它们的组合物，以及该化合物和组合物在治疗病毒感染中的用途。
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9.发明授权公开(公告)号：US08598193B2
公开(公告)日：2013-12-03
申请号：US10585230
申请日：2004-12-24
申请人： Silas Bond , Vanessa Anne Sanford , John Nicholas Lambert , Chin Yu Lim , Jeffrey Peter Mitchell , Alistair George Draffan , Roland Henry Nearn
发明人： Silas Bond , Vanessa Anne Sanford , John Nicholas Lambert , Chin Yu Lim , Jeffrey Peter Mitchell , Alistair George Draffan , Roland Henry Nearn
IPC分类号： A61K31/44 , C07D491/00
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/424 , A61K31/4353 , C07D471/14 , C07D487/14 , C07D519/00
摘要： Compounds of formula (I), and their use as in the treatment of infections involving viruses of the Pneumovirinae sub-family (RSV) are disclosed. In the formula ring (A) may be phenyl, pyridyl etc., (B—C) may be CH2—CH2 etc., (R1) may be phenyl and substituted forms thereof, (R2) may be assorted substituents.
摘要翻译： 公开了式（I）化合物及其在治疗涉及肺炎链球菌属亚型（RSV）病毒的感染中的用途。 在式中，环（A）可以是苯基，吡啶基等，（B-C）可以是CH 2 -CH 2等，（R 1）可以是苯基及其取代形式，（R2）可以是各种取代基。
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10.发明申请POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS 失效用于治疗呼吸道感染相关病毒的多环质药物公开(公告)号：US20100021458A1
公开(公告)日：2010-01-28
申请号：US12443177
申请日：2007-09-26
申请人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Anne Mayes
发明人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Anne Mayes
IPC分类号： A61K31/437 , C07D471/04 , A61K31/7056 , A61K39/42 , A61P31/12
CPC分类号： A61K39/42 , A61K31/437 , A61K31/4375 , A61K31/501 , A61K31/7056 , C07D471/04 , C07D471/14
摘要： The present invention relates to polycyclic antiviral compounds, and salts thereof, methods for their preparation and compositions containing them, and the use of the compounds and composition in the treatment of viral infections.
摘要翻译： 本发明涉及多环抗病毒化合物及其盐，其制备方法和含有它们的组合物，以及该化合物和组合物在治疗病毒感染中的用途。
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