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1.发明授权
公开(公告)号：US5342851A
公开(公告)日：1994-08-30
申请号：US958193
申请日：1992-10-07
IPC分类号： C07D417/04 , A61K31/425
CPC分类号： C07D417/04
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本文所定义：mpounds可用作血小板聚集抑制剂和粘附分子抑制剂，可用于药物组合物和治疗再灌注血栓形成的方法 患者受伤。
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2.发明授权
公开(公告)号：US5457212A
公开(公告)日：1995-10-10
申请号：US315668
申请日：1994-09-30
IPC分类号： A61K31/38 , A61P9/00 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/02 , C07B57/00 , C07D495/04 , C07D495/02 , C07D401/02 , C07D409/04 , C07D411/04
CPC分类号： C07D495/04
摘要： A process for the preparation of enantiomerically pure thienopyran derivatives of the formula ##STR1## is described. The thienopyran derivatives are relaxants of smooth muscle tone and as such are useful in vascular tissue for the treatment of hypertension disease, angina and other vascular disorders characterized by poor regional perfusion.
摘要翻译： 描述了制备具有式
的对映体纯的噻吩并吡喃衍生物的方法。 噻吩衍生物是平滑肌张力的松弛剂，因此在血管组织中可用于治疗以区域性灌注不良为特征的高血压疾病，心绞痛和其他血管疾病。 -
3.发明授权Substituted pyrimidinylaminothiazole derivatives useful as platelet aggregation inhibitors 失效可用作血小板聚集抑制剂的取代的嘧啶基氨基噻唑衍生物
公开(公告)号：US5665724A
公开(公告)日：1997-09-09
申请号：US446267
申请日：1995-05-22
IPC分类号： C07D417/12 , C07D521/00 , A61K31/33 , A61K31/425 , C07D239/02 , C07D411/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/12
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并可提供于药物组合物中 以及治疗患者再灌注血栓形成的方法。 还包括用于制备本发明化合物的新型中间体。
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4.发明授权Substituted pyrimidinylaminothiazole derivatives useful as platelet aggreggation inhibitors 失效可用作血小板聚集抑制剂的取代的嘧啶基氨基噻唑衍生物
公开(公告)号：US5530000A
公开(公告)日：1996-06-25
申请号：US171804
申请日：1993-12-22
IPC分类号： C07D417/12 , C07D521/00 , C07D277/28 , A61K31/425
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/12
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并可提供于药物组合物 以及治疗患者再灌注血栓形成的方法。 还包括用于制备本发明化合物的新型中间体。
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公开(公告)号：US07928246B2
公开(公告)日：2011-04-19
申请号：US12423948
申请日：2009-04-15
申请人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
发明人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
IPC分类号： C07D209/44
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.
摘要翻译： 本发明涉及式（I）的化合物，这些化合物的制备方法，组合物，中间体及其衍生物以及用于治疗葡糖激酶介导的病症。 更具体地，本发明的化合物是可用于治疗疾病的葡糖激酶调节剂，包括但不限于II型糖尿病。
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6.发明授权Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides 有权取代的苯并咪唑，苯并三唑和苯并咪唑酮-O-葡糖苷公开(公告)号：US07816330B2
公开(公告)日：2010-10-19
申请号：US12557629
申请日：2009-09-11
申请人： Maud Urbanski
发明人： Maud Urbanski
CPC分类号： C07H15/26
摘要： This invention relates to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
摘要翻译： 本发明涉及取代的苯并咪唑-O-葡糖苷，苯并三唑-O-葡糖苷和苯并咪唑酮-O-葡糖苷，含有它们的组合物，以及使用它们的方法，例如用于治疗或预防糖尿病和综合征X.
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7.发明授权Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides 有权取代的苯并咪唑，苯并三唑和苯并咪唑酮-O-葡糖苷公开(公告)号：US07511020B2
公开(公告)日：2009-03-31
申请号：US11453727
申请日：2006-06-15
申请人： Maud Urbanski
发明人： Maud Urbanski
CPC分类号： C07H15/26
摘要： This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
摘要翻译： 本发明涉及取代的苯并咪唑-O-葡萄糖苷，苯并三唑-O-葡糖苷和苯并咪唑酮-O-葡糖苷，含有它们的组合物，以及使用它们的方法，例如用于治疗或预防糖尿病和综合征X.
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公开(公告)号：US07129220B2
公开(公告)日：2006-10-31
申请号：US10903233
申请日：2004-07-30
摘要： Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
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9.发明授权Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides 有权取代的苯并咪唑，苯并三唑和苯并咪唑酮-O-葡糖苷公开(公告)号：US07094764B2
公开(公告)日：2006-08-22
申请号：US10903234
申请日：2004-07-30
申请人： Maud Urbanski
发明人： Maud Urbanski
CPC分类号： C07H15/26
摘要： This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
摘要翻译： 本发明涉及取代的苯并咪唑-O-葡萄糖苷，苯并三唑-O-葡糖苷和苯并咪唑酮-O-葡糖苷，含有它们的组合物，以及使用它们的方法，例如用于治疗或预防糖尿病和综合征X.
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公开(公告)号：US20050037980A1
公开(公告)日：2005-02-17
申请号：US10903136
申请日：2004-07-30
申请人： Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
发明人： Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7052 , C07H20060101 , C07H1/00 , C07H5/04 , C07H5/06 , C07H7/06 , C07H17/02
CPC分类号： C07H7/06 , Y10S514/866 , Y10S514/909
摘要： This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
摘要翻译： 本发明涉及取代的稠合杂环C糖苷，含有它们的组合物，以及使用它们的方法，例如用于治疗或预防糖尿病和综合征X.
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