公开(公告)号：US20160000967A1

公开(公告)日：2016-01-07

申请号：US14769769

申请日：2014-02-21

申请人： Pedro LYLYK ,  CARDIATIS S.A.

发明人： Pedro Lylyk ,  Noureddine Frid ,  Laurence Gebhart ,  Nils Köntges

IPC分类号： A61L27/28 ,  B05D3/02 ,  A61L27/54 ,  B05D1/18 ,  C07F9/38 ,  A61L27/04

CPC分类号： A61L27/28 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/21 ,  A61L2300/41 ,  A61L2300/42 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/0236 ,  B05D3/0245 ,  C07F9/386

摘要： An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.

摘要翻译： 一种可植入医疗装置，其包括（a）金属底物和（b）双膦酸盐，其中所述双膦酸盐中所含的两个磷原子共价连接到相同的碳原子上。 双膦酸盐连续地涂覆金属基材的外表面作为单层和最外层。 双膦酸盐的至少一个膦酸酯部分共价并直接键合到金属基底的外表面和/或共价键合到涂层中的另一个二膦酸分子。

公开(公告)号：US20220218871A1

公开(公告)日：2022-07-14

申请号：US17710491

申请日：2022-03-31

申请人： Pedro Lylyk ,  CARDIATIS S.A.

发明人： Pedro Lylyk ,  Noureddline Frid ,  Laurence Gebhart ,  Nils Köntges

IPC分类号： A61L27/28 ,  A61L27/34 ,  A61L31/10 ,  A61L27/04 ,  A61L27/54 ,  B05D1/18 ,  B05D3/02 ,  C07F9/38

摘要： An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.

公开(公告)号：US10076434B2

公开(公告)日：2018-09-18

申请号：US14897868

申请日：2014-06-13

申请人： CARDIATIS S.A.

发明人： Noureddine Frid ,  Nathalie Simao ,  Aurélie Masquelier ,  Laurence Gebhart

IPC分类号： A61F2/06 ,  A61F2/966 ,  A61F2/95 ,  A61F2/92

CPC分类号： A61F2/966 ,  A61F2/92 ,  A61F2002/9534 ,  A61F2002/9665

摘要： An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft. When the intraluminal apparatus is in a delivery configuration, the distal portion of the holding means is disposed around the proximal portion of the stent and defines an overlapping region of the holding means and the stent. The ratio L(10)/L(2)Comp of the length of the overlapping region, L(10), to the length of the self-expanding stent, L(2)Comp, in their compressed state is at least 5% and at most 30%.

公开(公告)号：US20160113795A1

公开(公告)日：2016-04-28

申请号：US14897868

申请日：2014-06-13

申请人： CARDIATIS S.A.

发明人： Noureddine Frid ,  Nathalie Simao ,  Aurélie Masquelier ,  Laurence Gebhart

IPC分类号： A61F2/966

CPC分类号： A61F2/966 ,  A61F2/92 ,  A61F2002/9534 ,  A61F2002/9665

摘要： An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen,(b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft.When the intraluminal apparatus is in a delivery configuration, the distal portion of the holding means is disposed around the proximal portion of the stent and defines an overlapping region of the holding means and the stent. The ratio L(10)/L(2)Comp of the length of the overlapping region, L(10), to the length of the self-expanding stent, L(2)Comp, in their compressed state is at least 5% and at most 30%.

摘要翻译： 一种管腔内装置，用于递送沿着纵向轴线从近侧延伸到远侧的自扩张支架。 它包括输送构型（a）具有沿其纵向轴线的内腔的收缩护套，并且可滑动地覆盖在内腔远侧的支架接收区域，（b）纵向设置在管腔内装置中的内轴，至少一个远端 所述内轴的一部分设置在所述护套内，（c）所述自扩张支架处于设置在所述内腔的支架接收区域内的压缩状态，（d）限定内腔的保持装置， 支架在护套中的近端固定在内轴上，以及（e）朝向管腔内装置的近侧放置的处理装置，能够相对 内轴。 当管腔内装置处于输送构造时，保持装置的远侧部分设置在支架的近端部分周围，并且限定保持装置和支架的重叠区域。 L（10）/ L（2）重叠区域长度L（10）与自膨胀支架长度L（2）Comp在压缩状态下的比例至少为5％ 至多30％。