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14 条记录 (耗时 0.02 秒)

    Baby walker
    1.
    发明授权
    Baby walker 有权
    宝贝步行者

    公开(公告)号：US08523742B2

    公开(公告)日：2013-09-03

    申请号：US12873324

    申请日：2010-09-01

    申请人： Peter Ar-Fu Lam ,  Chun-Ting Lee ,  Ting-Ku Tao

    发明人： Peter Ar-Fu Lam ,  Chun-Ting Lee ,  Ting-Ku Tao

    IPC分类号： A47D13/04

    CPC分类号： A47D13/04

    摘要： A baby walker is introduced herein. The baby walker includes a base and a pair of shoulder straps. The base is made by flexible materials such as plastics, or the similar materials. In one exemplary embodiment, the base of the baby walker may be packaged in a deflated form, and may be filled with air to form a shape as desired for an operation mode. The baby walker further includes a pair of shoulder straps which are firmly and fixedly attached in a peripheral upper side of the base. When the baby is placed in a central cavity of the base, the pair of the shoulder straps can be placed alongside the two shoulders of the baby. When the baby wears the baby walker and stands up, the whole baby walker is lifted up for a height above the ground level.

    摘要翻译： 这里介绍一个婴儿助行器。 婴儿步行者包括一个基座和一对肩带。 基座由柔性材料如塑料或类似材料制成。 在一个示例性实施例中，婴儿助行器的底部可以以放气形式包装，并且可以用空气填充以形成对于操作模式所需的形状。 婴儿助行器还包括一对肩带，其牢固且牢固地附接在基部的周边上侧。 当婴儿被放置在基座的中心腔中时，可以将一对肩带放置在婴儿的两个肩膀旁边。 当宝宝穿上婴儿步行者并站起来时，整个婴儿步行者被提升到地面以上的高度。

    BABY WALKER
    2.
    发明申请
    BABY WALKER 有权

    公开(公告)号：US20120053022A1

    公开(公告)日：2012-03-01

    申请号：US12873324

    申请日：2010-09-01

    申请人： Peter Ar-Fu Lam ,  Chun-Ting Lee ,  Ting-Ku Tao

    发明人： Peter Ar-Fu Lam ,  Chun-Ting Lee ,  Ting-Ku Tao

    IPC分类号： A47D13/04

    CPC分类号： A47D13/04

    摘要： A baby walker is introduced herein. The baby walker includes a base and a pair of shoulder straps. The base is made by flexible materials such as plastics, or the similar materials. In one exemplary embodiment, the base of the baby walker may be packaged in a deflated form, and may be filled with air to form a shape as desired for an operation mode. The baby walker further includes a pair of shoulder straps which are firmly and fixedly attached in a peripheral upper side of the base. When the baby is placed in a central cavity of the base, the pair of the shoulder straps can be placed alongside the two shoulders of the baby. When the baby wears the baby walker and stands up, the whole baby walker is lifted up for a height above the ground level.

    摘要翻译： 这里介绍一个婴儿助行器。 婴儿步行者包括一个基座和一对肩带。 基座由柔性材料如塑料或类似材料制成。 在一个示例性实施例中，婴儿助行器的底部可以以放气形式包装，并且可以用空气填充以形成对于操作模式所需的形状。 婴儿助行器还包括一对肩带，其牢固且牢固地附接在基部的周边上侧。 当婴儿被放置在基座的中心腔中时，可以将一对肩带放置在婴儿的两个肩膀旁边。 当宝宝穿上婴儿步行者并站起来时，整个婴儿步行者被提升到地面以上的高度。

    Centrifugal force sensing device and reaction system on centrifugal force
    4.
    发明授权
    Centrifugal force sensing device and reaction system on centrifugal force 有权
    离心力传感装置及离心力反应系统

    公开(公告)号：US08186222B2

    公开(公告)日：2012-05-29

    申请号：US12487654

    申请日：2009-06-19

    申请人： Shian Wan ,  Yuan-Shi Liao ,  Chun-Ting Lee ,  Yao-Yuan Chang

    发明人： Shian Wan ,  Yuan-Shi Liao ,  Chun-Ting Lee ,  Yao-Yuan Chang

    IPC分类号： G01P3/18

    CPC分类号： G01P3/16 ,  G01P13/02

    摘要： A centrifugal force sensing device is disclosed, which includes a first rotating shaft, two first movable and two first fixing sleeves, a first and a second weight, two first and two second linkages, a restoration element, a first sensing unit for sensing centrifugal force, and two fixers. The two first movable sleeves are disposed through the first rotating shaft. The two first linkages are connected to the first weight and the two first movable sleeves. The restoration element having a fixing block and two first damping elements is disposed at the first rotating shaft. The two second linkages are connected to the second weight and the two first movable sleeves. The two first fixing sleeves are fixed at the first rotating shaft and respectively located between each of the two first movable sleeves and one of the two fixers.

    摘要翻译： 公开了一种离心力感测装置，其包括第一旋转轴，两个第一可移动和两个第一固定套，第一和第二配重，两个第一和第二第二连杆，恢复元件，用于感测离心力的第一感测单元 ，和两个固定器。 两个第一可动套筒通过第一旋转轴设置。 两个第一连接件连接到第一重物和两个第一可动套筒。 具有固定块和两个第一阻尼元件的修复元件设置在第一旋转轴上。 两个第二连杆连接到第二重物和两个第一可移动套管。 两个第一固定套筒固定在第一旋转轴上，分别位于两个第一可移动套筒和两个固定器中的一个之间。

    Three-dimensional model of human cortex
    6.
    发明授权
    Three-dimensional model of human cortex 有权

    公开(公告)号：US10087417B2

    公开(公告)日：2018-10-02

    申请号：US15136250

    申请日：2016-04-22

    申请人： William J. Freed ,  Chun-Ting Lee

    发明人： William J. Freed ,  Chun-Ting Lee

    IPC分类号： C12N5/079

    摘要： Disclosed herein are methods for differentiation of neuronal cells from stem cells, which produce a three-dimensional model of the neocortex structure. In some embodiments, the methods include culturing stem cells with at least one inhibitor of SMAD signaling and at least one inhibitor of fibroblast growth factor signaling for a period of time to result in formation of an embryoid body. The embryoid body is then cultured with at least one FGF (for example, basic FGF) for a period of time sufficient to produce a neuroepithelial (NE) rosette. The rosette is then isolated and cultured in suspension or adherent culture in the presence of at least one FGF for a period of time sufficient to produce cells with dorsal cortical identity and those cells are then cultured in the substantial absence of trophic factors for a period of time sufficient to form a neocortical organoid.

    MODELING CONNECTIONS BETWEEN DOPAMINERGIC NEURONS AND THE CEREBRAL CORTEX
    9.
    发明申请
    MODELING CONNECTIONS BETWEEN DOPAMINERGIC NEURONS AND THE CEREBRAL CORTEX 审中-公开
    多巴胺神经元与小脑神经元之间的建模连接

    公开(公告)号：US20160326490A1

    公开(公告)日：2016-11-10

    申请号：US15148527

    申请日：2016-05-06

    申请人： William J. Freed ,  Chun-Ting Lee

    发明人： William J. Freed ,  Chun-Ting Lee

    IPC分类号： C12N5/0793

    CPC分类号： C12N5/0619 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/41 ,  C12N2501/727 ,  C12N2502/088 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2506/08

    摘要： Disclosed are methods that include separately differentiating stem cells to form cortical neural progenitor cells and differentiating stem cells to form dopaminergic neural progenitor cells. The cortical progenitor cells are transferred to a first compartment of a culture dish and the dopaminergic progenitor cells are transferred to a second compartment of the culture dish, separated by a removable barrier. The cortical progenitor cells and dopaminergic progenitor cells are cultured in medium that promotes differentiation of cortical neurons and dopaminergic neurons, respectively. The barrier is then removed, creating a single chamber containing the cortical progenitor cells and the dopaminergic progenitor cells, separated by a gap. The cortical progenitor cells and the dopaminergic progenitor cells are then cultured in a single medium, which promotes further differentiation of the neurons and also supports formation of connections (such as synapses or synapse-like structures) between at least some of the cortical neurons and dopaminergic neurons.

    摘要翻译： 公开了包括单独分化干细胞以形成皮层神经祖细胞并分化干细胞以形成多巴胺能神经祖细胞的方法。 将皮质祖细胞转移到培养皿的第一隔室中，并将多巴胺能祖细胞转移到培养皿的第二隔室中，通过可除去的屏障分离。 皮质祖细胞和多巴胺能祖细胞分别在促进皮质神经元和多巴胺能神经元分化的培养基中培养。 然后除去屏障，产生含有皮质祖细胞和多巴胺能祖细胞的单室，由间隙分开。 然后将皮质祖细胞和多巴胺能祖细胞在单个培养基中培养，促进神经元的进一步分化，并且还支持至少一些皮质神经元和多巴胺能之间形成连接（例如突触或突触样结构） 神经元。

    THREE-DIMENSIONAL MODEL OF HUMAN CORTEX
    10.
    发明申请
    THREE-DIMENSIONAL MODEL OF HUMAN CORTEX 审中-公开
    人体牙科三维模型

    公开(公告)号：US20160312181A1

    公开(公告)日：2016-10-27

    申请号：US15136250

    申请日：2016-04-22

    申请人： William J. Freed ,  Chun-Ting Lee

    发明人： William J. Freed ,  Chun-Ting Lee

    IPC分类号： C12N5/079

    CPC分类号： C12N5/0618 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/91 ,  C12N2503/04 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2513/00

    摘要： Disclosed herein are methods for differentiation of neuronal cells from stem cells, which produce a three-dimensional model of the neocortex structure. In some embodiments, the methods include culturing stem cells with at least one inhibitor of SMAD signaling and at least one inhibitor of fibroblast growth factor signaling for a period of time to result in formation of an embryoid body. The embryoid body is then cultured with at least one FGF (for example, basic FGF) for a period of time sufficient to produce a neuroepithelial (NE) rosette. The rosette is then isolated and cultured in suspension or adherent culture in the presence of at least one FGF for a period of time sufficient to produce cells with dorsal cortical identity and those cells are then cultured in the substantial absence of trophic factors for a period of time sufficient to form a neocortical organoid.

    摘要翻译： 本文公开的是将神经元细胞与干细胞分化的方法，其产生新皮质结构的三维模型。 在一些实施方案中，所述方法包括用至少一种SMAD信号传导抑制剂和至少一种成纤维细胞生长因子信号传导抑制剂培养干细胞一段时间以导致胚状体的形成。 然后将胚状体与至少一种FGF（例如碱性FGF）一起培养足以产生神经上皮（NE）玫瑰花的时间。 然后将玫瑰花被分离并在至少一种FGF的存在下在悬浮或贴壁培养物中培养足以产生具有背皮质特性的细胞的时间，然后将这些细胞在基本上不存在营养因子的条件下培养一段时间 足以形成新皮质组织。