摘要:
Compounds comprising an aza-bicyclic portion and an aromatic portion linked via an optionally oxidized sulphur atom are disclosed. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要:
The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要:
Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic acetylcholine receptors and are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要:
An embodiment of a communication system includes a client device adapted to receive a location object that includes tracer information, and to perform one or more location object-based actions using the location object. The client device stores the tracer information and location object usage information, which describes the one or more location object-based actions that have been performed using the location object. The client device also sends the stored information to a server. The system also includes the server, which is adapted to receive the location object usage information and the tracer information reported by the client device. In an embodiment, the system also includes a service provider adapted to initiate a billing event, which may include generation and transmission of a bill to a sponsor entity based on an evaluation of the location object usage information and the tracer information reported by the client device.
摘要:
A system is disclosed for monitoring condition of a railways installation such as a points machine. The system includes a plurality of sensors (S1, S2, S3-SN) associated with elements of the installation for monitoring parameters indicative of operating capability of the installation. The system includes means (12, 23) for processing the monitored parameters to determine whether the parameters are changing relative to reference values and to determine whether the changes are indicative of an increased risk of malfunction in the installation. The processing means may include a digital computer programmed with condition monitoring and fault detection software. A method of monitoring condition of a railways installation is also disclosed.
摘要:
Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要:
A device (60) and method for measuring the roughness of a playing surface are described. The device includes a carriage (12) which can travel over the playing surface, a rotatable member (80) which can roll over the playing surface, a restraint (84) which constrains the rotatable member (80) to travel with the carriage (12) and a transducer (70) coupled to the rotatable member (80) and which can generate a signal representative of the height and/or lateral translation of the rotatable member.
摘要:
Methods for lipomodeling by peripherally administering a modulator of a Y receptor are provided. Methods may comprise reduction of a fat depot by administering a Y receptor antagonist proximally and/or directly to the site of the fat depot. Other methods comprise increasing or stabilizing a fat depot or fat graft by administering a Y receptor agonist proximally and/or directly to the site of the fat depot or fat graft. Also provided are methods for stimulating wound healing by administering a Y receptor agonist proximally to a wound site.
摘要:
A cementitious pipe as a tubular wall of fibre-reinforced cementitious pseudo strain hardening (PSH) matrix. The matrix and a wall thickness to diameter ratio within a range are such that the pipe exhibits characteristic behaviour in diametral quasi-static bending under a 3-edge bearing method. The behaviour is such that a stress versus relative displacement curve for the pipe exhibits a substantially linear elastic region having a first slope within first limits, and from the LOP to the MOR for the pipe, a PSH region which, beyond a possible transition region, has a slope which is less than that of the elastic region and is within second limits.
摘要:
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.