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公开(公告)号：US20050070520A1
公开(公告)日：2005-03-31
申请号：US10500517
申请日：2002-07-29
申请人： Peter Astles , Stephen Baker , Celine Bonnefous , Jean Vernier , Martine Keenan , Adam Sanderson
发明人： Peter Astles , Stephen Baker , Celine Bonnefous , Jean Vernier , Martine Keenan , Adam Sanderson
IPC分类号： C07D207/12 , C07D211/54 , C07D223/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/12 , C07D417/06 , A61K31/501 , A61K31/497 , A61K31/53
CPC分类号： C07D401/06 , C07D207/12 , C07D211/54 , C07D223/06 , C07D401/12 , C07D405/06 , C07D413/12 , C07D417/06
摘要： Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic acetylcholine receptors and are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要翻译： 公开了包含氮杂环状部分和通过硫原子连接的芳香族部分的化合物。 所公开的化合物是β4亚型烟碱乙酰胆碱受体的选择性调节剂，并且可用于治疗中枢神经系统和自主神经系统的功能障碍。
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公开(公告)号：US20070054912A1
公开(公告)日：2007-03-08
申请号：US11595149
申请日：2006-11-09
申请人： Peter Astles , Stephen Baker , Rowena Cube , Jose Martinez-Perez , Ana Mateo Herranz , Jean Vernier , Colin Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Sanderson , Colin Smith
发明人： Peter Astles , Stephen Baker , Rowena Cube , Jose Martinez-Perez , Ana Mateo Herranz , Jean Vernier , Colin Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Sanderson , Colin Smith
IPC分类号： A61K31/53 , C07D471/02 , A61K31/519 , A61K31/498 , A61K31/4745
CPC分类号： A61K31/46 , A61K31/55 , C07D451/04 , C07D451/14
摘要： Compounds comprising an aza-bicyclic portion and an aromatic portion linked via an optionally oxidized sulphur atom are disclosed. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要翻译： 公开了包含氮杂双环部分和通过任选氧化的硫原子连接的芳族部分的化合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。
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公开(公告)号：US20050182088A1
公开(公告)日：2005-08-18
申请号：US10500516
申请日：2002-07-29
申请人： Peter Astles , Stephen Baker , Rowena Cube , Jose Martinez-Perez , Ana Mateo Herranz , Jean Vernier , Colin Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Sanderson , Colin Smith
发明人： Peter Astles , Stephen Baker , Rowena Cube , Jose Martinez-Perez , Ana Mateo Herranz , Jean Vernier , Colin Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Sanderson , Colin Smith
IPC分类号： A61K31/46 , A61K31/55 , C07D451/04 , C07D451/14 , C07D471/02 , A61K31/4745 , C07D453/04
CPC分类号： A61K31/46 , A61K31/55 , C07D451/04 , C07D451/14
摘要： The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要翻译： 本发明涉及通过促进神经递质如乙酰胆碱，多巴胺和去甲肾上腺素的释放来调节神经传递的化合物。 更具体地，本发明涉及能够调节乙酰胆碱受体的硫代桥连芳基化合物和包含这些化合物的药物组合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。
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公开(公告)号：US07408067B2
公开(公告)日：2008-08-05
申请号：US10500517
申请日：2002-07-29
申请人： Peter Charles Astles , Stephen Richard Baker , Celine Bonnefous , Jean Michel Vernier , Martine Keenan , Adam Jan Sanderson
发明人： Peter Charles Astles , Stephen Richard Baker , Celine Bonnefous , Jean Michel Vernier , Martine Keenan , Adam Jan Sanderson
IPC分类号： C07D211/22 , C07D401/00
CPC分类号： C07D401/06 , C07D207/12 , C07D211/54 , C07D223/06 , C07D401/12 , C07D405/06 , C07D413/12 , C07D417/06
摘要： Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic acetylcholine receptors and are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要翻译： 公开了包含氮杂环状部分和通过硫原子连接的芳香族部分的化合物。 所公开的化合物是β4亚型烟碱乙酰胆碱受体的选择性调节剂，并且可用于治疗中枢神经系统和自主神经系统的功能障碍。
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5.发明授权3-bicycloaryl-2-aminomethyl bicycloalkanes as serotonine reuptake inhibitors 失效3-双环芳基-2-氨基甲基双环烷烃作为血清素再摄取抑制剂公开(公告)号：US06384281B1
公开(公告)日：2002-05-07
申请号：US09958218
申请日：2001-10-03
IPC分类号： A61K3144
CPC分类号： C07C233/58 , C07C211/30 , C07C215/64 , C07C217/74 , C07C2602/20 , C07C2602/22 , C07D209/14 , C07D209/18 , C07D333/60
摘要： A pharmaceutical compound of formula (I) in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholino group, said group being optionally substituted with 1 to 3 C1-4alkyl substituents, R3 is a naphythyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; or a salt or ester thereof.
摘要翻译： 式（I）的药物化合物，其中R 1和R 2各自为氢或C 1-4烷基，或R 1和R 2与它们所连接的氮原子一起形成氮杂环丁烷基，吡咯烷基，哌啶基，哌嗪基或吗啉代基， 所述基团任选被1至3个C 1-4烷基取代基取代，R 3是萘基，吲哚基，苯并噻吩基，苯并呋喃基，苯并噻唑基，喹啉基或异喹啉基，所述基团任选被取代，n是1或2; 或其盐或酯。
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公开(公告)号：US20160075665A1
公开(公告)日：2016-03-17
申请号：US14888306
申请日：2014-05-01
申请人： Sanjay GARG , Martine KEENAN , Adam MCCLUSKEY , Andrew STEVENS , NEOCULI PTY LTD
发明人： Stephen Page , Sanjay Garg , Martine Keenan , Adam McCluskey , Andrew Stevens
IPC分类号： C07D239/50 , A01N47/44 , A61K45/06 , A01N43/54 , A61K31/505 , C07C281/18 , A61K31/155
CPC分类号： C07D239/50 , A01N43/54 , A01N47/44 , A61K31/14 , A61K31/155 , A61K31/17 , A61K31/175 , A61K31/381 , A61K31/404 , A61K31/505 , A61K45/06 , C07C281/08 , C07C281/16 , C07C281/18 , C07C323/45 , C07C337/08 , C07D209/14 , C07D209/40 , C07D213/53 , C07D215/12 , C07D239/48 , C07D251/48 , C07D251/54 , C07D251/66 , C07D295/125 , C07D307/56 , C07D333/58 , C07F9/6512 , A61K2300/00
摘要： The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
摘要翻译： 本发明提供式（I）化合物，以及使用式（I）化合物治疗或预防受试者细菌感染的方法。 本发明还提供式（I）化合物在制备用于治疗受试者的细菌感染的药物中的用途。 本发明还提供了用于治疗或预防受试者的细菌感染的方法中的医疗装置以及包含本发明的组合物的医疗装置。
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公开(公告)号：US07148236B2
公开(公告)日：2006-12-12
申请号：US10500516
申请日：2002-07-29
申请人： Peter Charles Astles , Stephen Richard Baker , Rowena Villanueva Cube , Jose Antonio Martinez-Perez , Ana Isabel Mateo Herranz , Jean Michel Vernier , Colin Peter Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Jan Sanderson , Colin William Smith
发明人： Peter Charles Astles , Stephen Richard Baker , Rowena Villanueva Cube , Jose Antonio Martinez-Perez , Ana Isabel Mateo Herranz , Jean Michel Vernier , Colin Peter Dell , Sonia Gutierrez , Lourdes Prieto , Martine Keenan , Adam Jan Sanderson , Colin William Smith
IPC分类号： A01N43/42 , A61K31/44 , C07D451/02 , C07D451/04 , C07D451/06
CPC分类号： A61K31/46 , A61K31/55 , C07D451/04 , C07D451/14
摘要： The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.
摘要翻译： 本发明涉及通过促进神经递质如乙酰胆碱，多巴胺和去甲肾上腺素的释放来调节神经传递的化合物。 更具体地，本发明涉及能够调节乙酰胆碱受体的硫代桥连芳基化合物和包含这些化合物的药物组合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。
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