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1.发明授权Compositions and methods for diminishing viral infection and inflammation associated with viral infection 有权用于减少与病毒感染相关的病毒感染和炎症的组合物和方法公开(公告)号：US09006194B2
公开(公告)日：2015-04-14
申请号：US13140521
申请日：2009-12-17
IPC分类号： A61K31/713 , A61K31/7105 , A61K31/711 , A61K31/7125 , C12N15/117
CPC分类号： A61K31/713 , A61K31/7105 , A61K31/711 , A61K31/7125 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/332 , G01N2500/10
摘要： The invention relates to compositions and methods for preventing and diminishing virus infection. The invention further relates to compositions and methods for diminishing inflammation associated with viral infection. The invention also relates to compositions and methods for interfering with TLR activation, and thereby diminishing inflammation associated with viral infection.
摘要翻译： 本发明涉及用于预防和减少病毒感染的组合物和方法。 本发明还涉及用于减少与病毒感染相关的炎症的组合物和方法。 本发明还涉及用于干扰TLR活化，从而减少与病毒感染相关的炎症的组合物和方法。
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2.发明申请Role of PI3K P110 Delta Signaling in Retroviral Infection and Replication 审中-公开PI3K P110 Delta信号在逆转录病毒感染和复制中的作用公开(公告)号：US20130116267A1
公开(公告)日：2013-05-09
申请号：US13809713
申请日：2011-07-13
IPC分类号： A61K31/52 , A61K31/506 , A61K31/519
CPC分类号： A61K38/45 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C12N9/1205 , C12N15/8509 , C12N2760/16111
摘要： The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes a method of inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HTV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K P110 delta.
摘要翻译： 本发明包括用于调节PI3Kp110δ作为抗逆转录病毒疗法的组合物和方法。 本发明包括在细胞中抑制p110δ，PI3Kp110δ信号通路的成分或其任何组合的方法，作为用于治疗逆转录病毒感染的抗逆转录病毒治疗方法，例如HTV。 本发明包括通过使细胞与有效量的包含PI3KP110δ的抑制剂的组合物接触来调节感染逆转录病毒的细胞中的PI3Kp110δ的方法。
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3.发明申请Compositions and Methods for Preventing or Treating Influenza Virus Infection 审中-公开用于预防或治疗流感病毒感染的组合物和方法公开(公告)号：US20120184519A1
公开(公告)日：2012-07-19
申请号：US13418045
申请日：2012-03-12
IPC分类号： A61K31/58 , A61K31/52 , A61K31/506 , C12N5/071 , A61K31/55 , A61P31/16 , A61P37/02 , A61P29/00 , A61K31/522 , A61K31/5377
CPC分类号： A61K38/45 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C12N9/1205 , C12N15/8509 , C12N2760/16111
摘要： The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HIV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K p110 delta.
摘要翻译： 本发明包括用于调节PI3Kp110δ作为抗逆转录病毒疗法的组合物和方法。 本发明包括在细胞中抑制p110δ，PI3Kp110δ信号通路的组分或其任何组合，作为用于治疗逆转录病毒感染的抗逆转录病毒治疗方法，例如HIV。 本发明包括通过使细胞与有效量的包含PI3Kp110δ的抑制剂的组合物接触来调节感染逆转录病毒的细胞中的PI3Kp110δ的方法。
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4.发明申请Role of PI3K p110 delta Signaling in Retroviral Infection and Replication 审中-公开PI3K p110三角信号在逆转录病毒感染和复制中的作用公开(公告)号：US20110135655A1
公开(公告)日：2011-06-09
申请号：US12835474
申请日：2010-07-13
CPC分类号： A61K38/45 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C12N9/1205 , C12N15/8509 , C12N2760/16111
摘要： The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HIV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K p110 delta.
摘要翻译： 本发明包括用于调节PI3Kp110δ作为抗逆转录病毒疗法的组合物和方法。 本发明包括在细胞中抑制p110δ，PI3Kp110δ信号通路的组分或其任何组合，作为用于治疗逆转录病毒感染的抗逆转录病毒治疗方法，例如HIV。 本发明包括通过使细胞与有效量的包含PI3Kp110δ的抑制剂的组合物接触来调节感染逆转录病毒的细胞中的PI3Kp110δ的方法。
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