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公开(公告)号：US6091975A
公开(公告)日：2000-07-18
申请号：US053272
申请日：1998-04-01
CPC分类号： A61B5/14865 , A61B2010/008
摘要： An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.
摘要翻译： 一种药剂检测装置，包括具有用于刺穿患者皮肤的多个微突起（4）的板（6）。 每个微突起物（4）上都有一个电极（14,16和18），用于检测患者组织液中药剂的存在。
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公开(公告)号：US08663155B2
公开(公告)日：2014-03-04
申请号：US11347779
申请日：2006-02-02
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。
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3.发明授权Formulations for coated microprojections containing non-volatile counterions 有权含有非挥发性抗衡离子的涂层微注射剂的配方公开(公告)号：US08920817B2
公开(公告)日：2014-12-30
申请号：US12583761
申请日：2009-08-24
申请人： Mahmoud Ameri , Wei-Qi Lin , Michel J. N. Cormier , Yuh-Fun Maa
发明人： Mahmoud Ameri , Wei-Qi Lin , Michel J. N. Cormier , Yuh-Fun Maa
CPC分类号： A61K9/0021 , A61K9/0014 , A61K47/02 , A61K47/12 , Y02A50/471 , Y02A50/478
摘要： The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
摘要翻译： 本发明提供一种用于涂覆一种或多种微注射剂的制剂，其减少或最小化来自涂层的抗衡离子的损失以达到pH稳定的制剂。
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公开(公告)号：US20060200069A1
公开(公告)日：2006-09-07
申请号：US11347779
申请日：2006-02-02
申请人： Michel Cormier , Wendy Young , Kofi Nyam , Peter Daddona , Wei-Qi Lin
发明人： Michel Cormier , Wendy Young , Kofi Nyam , Peter Daddona , Wei-Qi Lin
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。
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5.发明申请Formulations for coated microprojections containing non-volatile counterions 审中-公开含有非挥发性抗衡离子的涂层微注射剂的配方公开(公告)号：US20100221305A1
公开(公告)日：2010-09-02
申请号：US12583761
申请日：2009-08-24
申请人： Mahmoud Armeri , Wei-Qi Lin , Michel J.N. Cormier , Yuh-Fun Maa
发明人： Mahmoud Armeri , Wei-Qi Lin , Michel J.N. Cormier , Yuh-Fun Maa
IPC分类号： A61K9/70 , A61K38/20 , A61K31/445 , A61K38/29 , A61K38/50 , A61K38/21 , A61K38/19 , A61K38/48 , A61P31/04 , A61P31/12 , A61P29/00 , A61P3/04 , A61P19/02 , A61P25/24 , A61P3/10 , A61P25/06 , A61P35/00 , A61P25/16 , A61P5/18 , B05D7/00
CPC分类号： A61K9/0021 , A61K9/0014 , A61K47/02 , A61K47/12 , Y02A50/471 , Y02A50/478
摘要： The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
摘要翻译： 本发明提供一种用于涂覆一种或多种微注射剂的制剂，其减少或最小化来自涂层的抗衡离子的损失以达到pH稳定的制剂。
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公开(公告)号：US07087035B2
公开(公告)日：2006-08-08
申请号：US09733506
申请日：2000-12-08
申请人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
发明人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/425 , A61M2037/0023 , A61M2037/0046
摘要： A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.
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公开(公告)号：US20050085766A1
公开(公告)日：2005-04-21
申请号：US10984499
申请日：2004-11-09
申请人： Joseph Trautman , Michel Cormier , Kellee Eng , Wei-Qi Lin , Hyunok Kim , Sara Sendelbeck , Armand Neukermans , Bruce Edwards , Wai-Loong Lim , Andrew Poutiatine , J. Gyory
发明人： Joseph Trautman , Michel Cormier , Kellee Eng , Wei-Qi Lin , Hyunok Kim , Sara Sendelbeck , Armand Neukermans , Bruce Edwards , Wai-Loong Lim , Andrew Poutiatine , J. Gyory
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/425 , A61M2037/0023 , A61M2037/0046
摘要： A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.
摘要翻译： 用于通过微突触强化皮肤刺穿的装置和方法涉及预拉伸皮肤以增强当微突起被压入皮肤时的通路形成。 可扩张装置包括接触皮肤表面的相对端的皮肤，使得当装置膨胀时，皮肤被拉伸。 将皮肤置于约0.01至约10兆帕，优选约0.05至2兆帕的张力下。 该装置具有穿过皮肤的多个微突起，同时皮肤被扩张装置拉伸。 另一种拉伸装置采用吸力进行皮肤拉伸。
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公开(公告)号：US06562014B2
公开(公告)日：2003-05-13
申请号：US09737882
申请日：2000-12-14
申请人： Wei-Qi Lin , Michel J. N. Cormier , Felix Theeuwes
发明人： Wei-Qi Lin , Michel J. N. Cormier , Felix Theeuwes
IPC分类号： A61M100
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150984 , A61B10/0045 , A61B17/205 , A61B2010/0009 , A61B2010/008 , A61M2037/0007
摘要： A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 &mgr;m to 400 &mgr;m) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.
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