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公开(公告)号：US08183371B2
公开(公告)日：2012-05-22
申请号：US12913917
申请日：2010-10-28
IPC分类号： C07D241/00
CPC分类号： C07D401/14 , C07D403/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，L，X和Y如本文所定义。
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2.发明授权Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors 有权氨基 - 吡咯烷 - 氮杂环丁烷二酰胺作为单酰基甘油脂肪酶抑制剂公开(公告)号：US08575363B2
公开(公告)日：2013-11-05
申请号：US13277734
申请日：2011-10-20
IPC分类号： C07D207/10 , A61K31/397
CPC分类号： A61K31/4025 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/428 , A61K31/4725 , A61K31/506 , A61K31/517 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R1, and R2 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映异构体，非对映异构体及其药学上可接受的盐由式（I）表示如下：其中Y，Z和R 1和R 2在本文中定义。
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3.发明申请公开(公告)号：US20110105527A1
公开(公告)日：2011-05-05
申请号：US12913917
申请日：2010-10-28
IPC分类号： A61K31/4965 , C07D401/14 , C07D401/02 , A61P19/02 , A61P25/06 , A61P25/00 , A61P29/00 , A61P17/02 , A61P17/00 , A61P3/10 , A61P1/00 , A61P15/00 , A61P35/00 , A61P25/16 , A61P25/28 , A61P25/24 , A61P25/30 , A61P13/02
CPC分类号： C07D401/14 , C07D403/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，L，X和Y如本文所定义。
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4.发明申请公开(公告)号：US20120202824A1
公开(公告)日：2012-08-09
申请号：US13451652
申请日：2012-04-20
IPC分类号： A61K31/497 , A61P25/24 , A61P25/16 , A61P25/30 , A61P11/00 , A61P1/04 , A61P13/00 , A61P15/00 , A61P1/12 , A61P9/00 , A61P25/00 , A61P25/32
CPC分类号： C07D401/14 , C07D403/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，L，X和Y如本文所定义。
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5.发明申请AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS 有权氨基吡咯烷酮 - 亚氨基二异氰酸酯作为单羟乙基脂肪酶抑制剂公开(公告)号：US20120101081A1
公开(公告)日：2012-04-26
申请号：US13277734
申请日：2011-10-20
IPC分类号： A61K31/4725 , A61P25/00 , C07D403/14 , C07D417/14 , C07D403/12
CPC分类号： A61K31/4025 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/428 , A61K31/4725 , A61K31/506 , A61K31/517 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R1, and R2 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映异构体，非对映异构体及其药学上可接受的盐由式（I）表示如下：其中Y，Z和R 1和R 2在本文中定义。
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公开(公告)号：US08513271B2
公开(公告)日：2013-08-20
申请号：US12913966
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
发明人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC分类号： A01N43/54
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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公开(公告)号：US08293750B2
公开(公告)日：2012-10-23
申请号：US13451652
申请日：2012-04-20
IPC分类号： A61K31/4965
CPC分类号： C07D401/14 , C07D403/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
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公开(公告)号：US08450303B2
公开(公告)日：2013-05-28
申请号：US12765179
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D295/192 , C07D405/06
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08445477B2
公开(公告)日：2013-05-21
申请号：US12765048
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/541 , C07D205/04 , C07D401/12 , C07D403/04 , C07D409/06 , C07D413/12 , C07D471/04 , C07D491/048
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08367653B2
公开(公告)日：2013-02-05
申请号：US12765076
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark MacIelag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark MacIelag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D401/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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