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公开(公告)号：US08821838B2
公开(公告)日：2014-09-02
申请号：US13592897
申请日：2012-08-23
IPC分类号： A61K49/04 , A61K31/695 , A61B5/055
CPC分类号： A61K49/0428 , B82Y5/00 , C07F7/1804 , Y10T428/2982
摘要： The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; t为0,1或2; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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公开(公告)号：US20100278734A1
公开(公告)日：2010-11-04
申请号：US12431884
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00 , Y10S977/773 , Y10S977/928
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
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公开(公告)号：US20100166666A1
公开(公告)日：2010-07-01
申请号：US12344608
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
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公开(公告)号：US08728529B2
公开(公告)日：2014-05-20
申请号：US12344606
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US08574549B2
公开(公告)日：2013-11-05
申请号：US12344608
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
IPC分类号： A61K49/04
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多种纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US20100166665A1
公开(公告)日：2010-07-01
申请号：US12344606
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US08728440B2
公开(公告)日：2014-05-20
申请号：US13592853
申请日：2012-08-23
CPC分类号： A61K49/1848 , A61K49/04 , A61K49/0428 , B82Y5/00 , C07F7/1804 , C07F9/005 , Y10T428/2982
摘要： The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1和R 2在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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公开(公告)号：US20140056819A1
公开(公告)日：2014-02-27
申请号：US13592853
申请日：2012-08-23
CPC分类号： A61K49/1848 , A61K49/04 , A61K49/0428 , B82Y5/00 , C07F7/1804 , C07F9/005 , Y10T428/2982
摘要： The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1和R 2在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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公开(公告)号：US20100278749A1
公开(公告)日：2010-11-04
申请号：US12431899
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
摘要翻译： 提供了用至少一个净正电荷基团和至少一个净负电荷基团官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括核和壳。 壳包含多个硅烷部分; 多个的至少一个硅烷部分用净正电荷基团官能化，并且多个的至少一个硅烷部分用净带负电基团官能化。
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公开(公告)号：US20140056821A1
公开(公告)日：2014-02-27
申请号：US13592897
申请日：2012-08-23
CPC分类号： A61K49/0428 , B82Y5/00 , C07F7/1804 , Y10T428/2982
摘要： The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; t为0,1或2; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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