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公开(公告)号：US08574549B2
公开(公告)日：2013-11-05
申请号：US12344608
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
IPC分类号： A61K49/04
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多种纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US20100166666A1
公开(公告)日：2010-07-01
申请号：US12344608
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
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公开(公告)号：US20100278749A1
公开(公告)日：2010-11-04
申请号：US12431899
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
摘要翻译： 提供了用至少一个净正电荷基团和至少一个净负电荷基团官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括核和壳。 壳包含多个硅烷部分; 多个的至少一个硅烷部分用净正电荷基团官能化，并且多个的至少一个硅烷部分用净带负电基团官能化。
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公开(公告)号：US08728529B2
公开(公告)日：2014-05-20
申请号：US12344606
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US20100166665A1
公开(公告)日：2010-07-01
申请号：US12344606
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US20100278734A1
公开(公告)日：2010-11-04
申请号：US12431884
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00 , Y10S977/773 , Y10S977/928
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
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公开(公告)号：US20100278748A1
公开(公告)日：2010-11-04
申请号：US12431892
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
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公开(公告)号：US20100166664A1
公开(公告)日：2010-07-01
申请号：US12344604
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
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9.发明授权Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same 有权用于X射线/计算机断层扫描的基于纳米颗粒的成像剂及其制备方法公开(公告)号：US09149545B2
公开(公告)日：2015-10-06
申请号：US12276817
申请日：2008-11-24
申请人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
发明人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
CPC分类号： A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01G35/00 , C01P2004/04 , C01P2004/64 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。 本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。
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10.发明申请NANOPARTICLE-BASED IMAGING AGENTS FOR X-RAY/COMPUTED TOMOGRAPHY AND METHODS FOR MAKING SAME 有权用于X射线/计算机图像的基于纳米脂的成像剂及其制备方法公开(公告)号：US20090087383A1
公开(公告)日：2009-04-02
申请号：US12276817
申请日：2008-11-24
申请人： Peter John Bonitatibus, JR. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
发明人： Peter John Bonitatibus, JR. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
IPC分类号： A61K49/04
CPC分类号： A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01G35/00 , C01P2004/04 , C01P2004/64 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。 本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。
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