公开(公告)号：US20100198033A1

公开(公告)日：2010-08-05

申请号：US12366466

申请日：2009-02-05

申请人： Peter KRULEVITCH ,  Donna SAVAGE ,  Lorin P. OLSON ,  Leif BOWMAN

发明人： Peter KRULEVITCH ,  Donna SAVAGE ,  Lorin P. OLSON ,  Leif BOWMAN

IPC分类号： A61B5/145

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849

摘要： A flexible indwelling biosensor includes an elongated framework formed from a flexible material (e.g., a Nitinol strip) with a body portion, a sharp head, a distal end, and a proximal end. The flexible indwelling sensor also includes a biosensor (such as an interstitial fluid glucose sensor) integrated with the elongated framework with the biosensor having a sensing element disposed over (for example, on or suspended over) at least one of the body portion or sharp head of the elongated framework. Moreover, the sharp head is disposed at the distal end of the elongated framework and the sharp head and at least the sensing element of the biosensor are configured for insertion into a target site (for example, a subcutaneous target site).

摘要翻译： 柔性留置生物传感器包括由具有主体部分，尖头，远端和近端的柔性材料（例如，镍钛诺带）形成的细长骨架。 柔性留置传感器还包括与细长框架集成的生物传感器（例如间质流体葡萄糖传感器），其中生物传感器具有设置在（例如，在其上或悬挂在其上）主体部分或尖头中的至少一个的感测元件 的细长框架。 此外，尖头设置在细长框架的远端并且尖锐头部，并且至少生物传感器的感测元件构造成用于插入目标部位（例如，皮下靶位点）。

公开(公告)号：US20100300897A1

公开(公告)日：2010-12-02

申请号：US12473953

申请日：2009-05-28

申请人： Donna SAVAGE ,  Peter Krulevitch ,  Mingqi Zhao

发明人： Donna SAVAGE ,  Peter Krulevitch ,  Mingqi Zhao

IPC分类号： G01N33/487 ,  G01N33/50

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/6846 ,  A61B2562/02

摘要： A flexible indwelling electrochemical-based biosensor includes an elongated framework and an integrated electrochemical-based biosensor. The elongated framework is formed of an electrically conductive flexible material (e.g., a Nitinol) with a body portion, a sharp head, a distal end and a proximal end. The integrated electrochemical-based biosensor (such as an electrochemical-based glucose sensor) is integrated with the elongated framework in that the biosensor has a sensing element that is disposed over the body portion or sharp head of the elongated framework and a portion of the elongated framework is configured as an electrode component that electrically cooperates with the sensing element. The electrode component can, for example, be configured to electrically cooperate as a working electrode, counter electrode, reference electrode or combined reference/counter electrode of the sensing element. Moreover, the sharp head is disposed at the distal end of the elongated framework and the sharp head, the electrode component and at least the sensing element of the biosensor are configured for insertion into a target site (for example, a subcutaneous target site).

摘要翻译： 柔性留置电化学基​​生物传感器包括细长框架和集成的基于电化学的生物传感器。 细长骨架由具有主体部分，尖头，远端和近端的导电柔性材料（例如镍钛诺）形成。 集成的基于电化学的生物传感器（例如基于电化学的葡萄糖传感器）与细长骨架集成在一起，因为生物传感器具有设置在细长框架的主体部分或尖头上的感测元件，并且细长的框架的一部分 框架被配置为与传感元件电气配合的电极部件。 电极部件例如可以被配置为电耦合作为感测元件的工作电极，对电极，参考电极或组合的参考/对电极。 此外，尖头设置在细长骨架的远端处，并且尖锐头部，电极部件和生物传感器的至少传感元件构造成用于插入目标部位（例如，皮下靶位点）。