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公开(公告)号：US20070224594A1
公开(公告)日：2007-09-27
申请号：US11698798
申请日：2007-01-26
申请人： Peter Lu , Michael Belmares , Johannes Schweizer , Jon Silver
发明人： Peter Lu , Michael Belmares , Johannes Schweizer , Jon Silver
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2500/02 , Y02A50/53 , Y02A50/60
摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.
摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。
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公开(公告)号：US20120141502A1
公开(公告)日：2012-06-07
申请号：US13265332
申请日：2010-04-20
申请人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
发明人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
IPC分类号： A61K39/395 , A61P31/20 , C40B30/04 , C12Q1/70 , C40B40/10
CPC分类号： G01N33/5748 , C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/025 , G01N2469/10
摘要： The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains.
摘要翻译： 本发明提供了用于检测样品中至少一种HPV病毒株的E6蛋白的抗体组合物。 受试抗体可用于检测样品中的致癌HPV E6蛋白，并且抗体可用于多种诊断和治疗应用，包括诊断和治疗癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。 本发明还公开了产生特异性结合至少两种HPV病毒株的E6蛋白的氨基末端的抗体的方法。
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公开(公告)号：US20100028855A1
公开(公告)日：2010-02-04
申请号：US12298133
申请日：2006-10-21
申请人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
发明人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
IPC分类号： C12Q1/70
CPC分类号： C07K16/1018 , G01N33/56983 , G01N2333/11
摘要： The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses.
摘要翻译： 本发明提供从其NS1蛋白检测流感B的方法。 NS1蛋白以临床样品中可检测的水平存在，并且可以使用针对乙型流感病毒而不与A型流感病毒或其他病毒结合的特异性抗体进行检测。
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公开(公告)号：US20100143884A1
公开(公告)日：2010-06-10
申请号：US12524565
申请日：2008-01-28
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2500/02 , Y02A50/53 , Y02A50/60
摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.
摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。
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