-
公开(公告)号：US20100028855A1
公开(公告)日：2010-02-04
申请号：US12298133
申请日：2006-10-21
申请人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
发明人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
IPC分类号： C12Q1/70
CPC分类号： C07K16/1018 , G01N33/56983 , G01N2333/11
摘要： The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses.
摘要翻译： 本发明提供从其NS1蛋白检测流感B的方法。 NS1蛋白以临床样品中可检测的水平存在，并且可以使用针对乙型流感病毒而不与A型流感病毒或其他病毒结合的特异性抗体进行检测。
-
公开(公告)号：US20100143884A1
公开(公告)日：2010-06-10
申请号：US12524565
申请日：2008-01-28
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2500/02 , Y02A50/53 , Y02A50/60
摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.
摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。
-
公开(公告)号：US20100120700A1
公开(公告)日：2010-05-13
申请号：US12606905
申请日：2009-10-27
申请人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
发明人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02
摘要： The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
摘要翻译： 本发明提供了用于治疗病原体感染，特别是人乳头瘤病毒感染的方法和组合物。 具体地，本发明提供了一种筛选方法，其涉及确定候选试剂对来自HPV的致癌菌株的E6蛋白与含有来自细胞蛋白MAGI-1的特定PDZ结构域的氨基酸序列的多肽的结合的影响 。 本发明提供了通过调节与MAGI-1的相互作用来治疗与病原体蛋白表达相关的疾病的方法，以及在这些方法中有用的许多分离的肽。 还提供了用于执行主题方法的套件。
-
公开(公告)号：US20090118301A1
公开(公告)日：2009-05-07
申请号：US12262023
申请日：2008-10-30
IPC分类号： A61K31/497 , A61K31/40 , A61K31/34 , C07D403/14 , C07D403/04 , A61K31/4164
CPC分类号： C07D209/14 , A61K31/34 , A61K31/40 , A61K31/4164 , A61K31/497 , C07D209/12 , C07D209/42 , C07D235/26 , C07D307/80
摘要： The invention provides compounds useful for treating or effecting prophylaxis of cancers, particularly cervical cancer.
摘要翻译： 本发明提供了可用于治疗或预防癌症，特别是宫颈癌的化合物。
-
公开(公告)号：US07312041B2
公开(公告)日：2007-12-25
申请号：US10630590
申请日：2003-07-29
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
-
公开(公告)号：US20090155921A1
公开(公告)日：2009-06-18
申请号：US12333219
申请日：2008-12-11
申请人： Peter S. Lu , Joseph Byerly , Christopher Kepner , Thomas M. Sherlock , Michael P. Belmares , Johannes Schweizer
发明人： Peter S. Lu , Joseph Byerly , Christopher Kepner , Thomas M. Sherlock , Michael P. Belmares , Johannes Schweizer
CPC分类号： G01N21/8483 , G01N21/274 , G01N21/276 , G01N2201/12792
摘要： The present invention provides a method and apparatus for reading test strips such as lateral flow test strips as used for the testing of various chemicals in humans and animals. A compact and portable device is provided that may be battery powered when used remotely from the laboratory and, may store test data until it can be downloaded to another database. Motive power during scanning of the test strip is by means of a spring and damper that is wound by the operator during the insertion of a test strip cassette holder prior to test.
摘要翻译： 本发明提供一种用于读取测试条的方法和装置，例如用于测试人和动物中的各种化学物质的横向流动测试条。 提供了一种紧凑型便携式设备，可在实验室远程使用电池供电，并可存储测试数据，直到可以下载到另一个数据库。 在测试条扫描期间的动力是借助于弹簧和阻尼器，其在测试之前插入测试条带盒座期间由操作者缠绕。
-
公开(公告)号：US07399467B2
公开(公告)日：2008-07-15
申请号：US11021949
申请日：2004-12-23
申请人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： A61K39/395
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
-
公开(公告)号：US20120052484A1
公开(公告)日：2012-03-01
申请号：US13212991
申请日：2011-08-18
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
-
公开(公告)号：US08048676B2
公开(公告)日：2011-11-01
申请号：US11650455
申请日：2007-01-05
IPC分类号： G01N33/53
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
-
公开(公告)号：US07972774B2
公开(公告)日：2011-07-05
申请号：US11881724
申请日：2007-07-27
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.035 秒)
