专利检索 ap:("Peter R. Guzzo" OR "Shuang Liu" OR "Kristen N. Ryan" OR "Bruce F. Molino" OR "Russell DeOrazio" OR "Richard E. Olson" OR "John E. Macor") AND inv:"Kristen N. Ryan" 第 1 页

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发明授权
2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权
标题翻译： 2,5-亚甲基和2,5-乙基 - 四氢苯并氮杂衍生物及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取

公开(公告)号：US09045468B2

公开(公告)日：2015-06-02

申请号：US13211678

申请日：2011-08-17

申请人： Peter R. Guzzo , Shuang Liu , Kristen N. Ryan , Bruce F. Molino , Russell DeOrazio , Richard E. Olson , John E. Macor

发明人： Peter R. Guzzo , Shuang Liu , Kristen N. Ryan , Bruce F. Molino , Russell DeOrazio , Richard E. Olson , John E. Macor

IPC分类号： A61K31/55 , C07D453/00 , C07D519/00

CPC分类号： C07D453/00 , C07D519/00

摘要： The compounds of the present invention are represented by the following 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives having formula (I): where the carbon atom designated * is in the R or S configuration when n is 1 and the substituents X and R1-R7 are as defined herein.

摘要翻译： 本发明的化合物由以下具有式（I）的2,5-亚甲基 - 和2,5-亚乙基 - 四氢苯并吖庚因衍生物表示：当n为1时，其中指定为*为R或S构型的碳原子，取代基X和R 1 -R 7如本文所定义。