公开(公告)号：US20240083991A1

公开(公告)日：2024-03-14

申请号：US18326335

申请日：2023-05-31

Applicant: Pfizer Inc. ,  The Brigham and Women's Hospital, Inc. ,  The General Hospital Corporation

Inventor： Paul B. Yu ,  James Reasoner Apgar ,  Susan Adam Benard ,  Stephen Peter Berasi ,  Christine Huard ,  Oleg Victorovich Kovalenko ,  Lidia Mosyak ,  Xianchun Tang ,  Kathleen Elisabeth Tumelty ,  Luca Troncone ,  Ying Zhong

IPC: C07K16/22 ,  A61P9/12

CPC classification number: C07K16/22 ,  A61P9/12 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US11597770B2

公开(公告)日：2023-03-07

申请号：US17154588

申请日：2021-01-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Sheryl Rubio Bowley ,  Joanne Elizabeth-Ayriss Elwell ,  Laura Lin ,  Jatin Narula ,  Chuenlei Parng ,  Debra Denene Pittman ,  Swapnil Rakhe ,  Chihyi Vincent Yu

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US20210246213A1

公开(公告)日：2021-08-12

申请号：US17154588

申请日：2021-01-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Sheryl Rubio Bowley ,  Joanne Elizabeth-Ayriss Elwell ,  Laura Lin ,  Jatin Narula ,  Chuenlei Parng ,  Debra Denene Pittman ,  Swapnil Rakhe ,  Chihyi Vincent Yu

IPC: C07K16/28

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US11840572B2

公开(公告)日：2023-12-12

申请号：US17378377

申请日：2021-07-16

Applicant: PFIZER INC.

Inventor： James Reasoner Apgar ,  Andrea Therese Hooper ,  Malgorzata Agnieszka Nocula-Lugowska ,  Lei Wu

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.

公开(公告)号：US11434292B2

公开(公告)日：2022-09-06

申请号：US16417859

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Fang Jin ,  Madan Katragadda ,  Divya Mathur ,  Lioudmila Gennadievna Tchistiakova

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

公开(公告)号：US10544212B2

公开(公告)日：2020-01-28

申请号：US15495172

申请日：2017-04-24

Applicant: Pfizer Inc.

Inventor： Laird Bloom ,  Karl Henry Nocka ,  James Reasoner Apgar ,  Matthew Allister Lambert ,  Mark A. Farmer

IPC: C07K16/24 ,  A61K39/395 ,  A61K39/00

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.

公开(公告)号：US20240076386A1

公开(公告)日：2024-03-07

申请号：US18174974

申请日：2023-02-27

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Sheryl Rubio Bowley ,  Joanne Elizabeth-Ayriss Elwell ,  Laura Lin ,  Jatin Narula ,  Chuenlei Parng ,  Debra Denene Pittman ,  Swapnil Rakhe ,  Chihyi Vincent Yu

IPC: C07K16/28

CPC classification number: C07K16/2854 ,  A61K2039/505

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US20240018244A1

公开(公告)日：2024-01-18

申请号：US18449867

申请日：2023-08-15

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Andrea Therese Hooper ,  Malgorzata Agnieszka Nocula-Lugowska ,  Lei Wu

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.

公开(公告)号：US20190382486A1

公开(公告)日：2019-12-19

申请号：US16417859

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Fang Jin ,  Madan Katragadda ,  Divya Mathur ,  Lioudmila Gennadievna Tchistiakova

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/30 ,  C07K16/40 ,  A61P35/00

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.