公开(公告)号：US20170327485A1

公开(公告)日：2017-11-16

申请号：US15492719

申请日：2017-04-20

申请人： Pfizer Inc.

发明人： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D241/20 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D475/00

摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：US10450297B2

公开(公告)日：2019-10-22

申请号：US15946117

申请日：2018-04-05

申请人： Pfizer, Inc.

发明人： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D241/20 ,  C07D475/00

摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：US20190047979A1

公开(公告)日：2019-02-14

申请号：US15946117

申请日：2018-04-05

申请人： Pfizer, Inc.

发明人： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC分类号： C07D401/12 ,  C07D475/00 ,  C07D241/20 ,  C07D417/14 ,  C07D417/12 ,  C07D239/48 ,  C07D405/14 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14

摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.