公开(公告)号：US20140080756A1

公开(公告)日：2014-03-20

申请号：US14083275

申请日：2013-11-18

Applicant: Pfizer Inc.

Inventor： Samit K. Bhattacharya ,  Kimberly O. Cameron ,  Dilinie P. Fernando ,  Kim F. McClure ,  Daniel W. Kung ,  Allyn T. Londregan ,  Suvi T.M. Orr

IPC: C07D471/10 ,  A61K31/506 ,  A61K31/53 ,  A61K31/435 ,  A61K31/497 ,  C07D491/056 ,  C07D513/04 ,  A61K45/06

CPC classification number: C07D471/10 ,  A61K31/435 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53 ,  A61K45/06 ,  C07D491/056 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention provides a compound of Formula (I) a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor.

Abstract translation: 本发明提供了其作为Ghrelin拮抗剂或反向激动剂的其中R 1，R 2，R a，L，Z，Z 1和Z 2如本文所定义的药用盐的式（I）化合物; 其药物组合物; 以及治疗由Ghrelin受体的拮抗作用介导的疾病，病症或病症的方法。

公开(公告)号：US20190047979A1

公开(公告)日：2019-02-14

申请号：US15946117

申请日：2018-04-05

Applicant: Pfizer, Inc.

Inventor： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC: C07D401/12 ,  C07D475/00 ,  C07D241/20 ,  C07D417/14 ,  C07D417/12 ,  C07D239/48 ,  C07D405/14 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：US20170327485A1

公开(公告)日：2017-11-16

申请号：US15492719

申请日：2017-04-20

Applicant: Pfizer Inc.

Inventor： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D239/48 ,  C07D241/20 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D475/00

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：US10450297B2

公开(公告)日：2019-10-22

申请号：US15946117

申请日：2018-04-05

Applicant: Pfizer, Inc.

Inventor： Michael J. Luzzio ,  Kevin D. Freeman-Cook ,  Samit K. Bhattacharya ,  Matthew M. Hayward ,  Catherine A. Hulford ,  Christopher L. Autry ,  Xumiao Zhao ,  Jun Xiao ,  Kendra L. Nelson

IPC: C07D401/12 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D241/20 ,  C07D475/00

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.