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公开(公告)号：US10550200B2
公开(公告)日：2020-02-04
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395 , A61K39/00
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20150306234A1
公开(公告)日：2015-10-29
申请号：US14638760
申请日：2015-03-04
Applicant: Pfizer Inc.
Inventor： James Apgar , Debra Pittman , Mark Stahl , Laura Lin , Justin Cohen
IPC: A61K47/48 , A61K38/37 , C07K14/755
CPC classification number: C07K14/755 , A61K38/00 , A61K38/37 , A61K47/61
Abstract: The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.
Abstract translation: 本公开内容提供FVIII的突变蛋白，生物相容性聚合物可以连接到其上，以增加突变蛋白的循环半衰期，以及这些突变蛋白和生物相容性聚合物的缀合物。
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公开(公告)号：US20230416405A1
公开(公告)日：2023-12-28
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
CPC classification number: C07K16/38 , A61K39/0011 , A61K38/4846 , A61K39/3955 , C12Y304/21021 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2317/21 , A61K2039/5158 , A61K2039/55522 , C07K2317/565 , C07K2317/622
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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Patent Agency Ranking
公开(公告)号：US10570189B2
公开(公告)日：2020-02-25
申请号：US14638760
申请日：2015-03-04
Applicant: Pfizer Inc.
Inventor： James Apgar , Debra Pittman , Mark Stahl , Laura Lin , Justin Cohen
IPC: C07K14/755 , A61K38/00 , A61K47/61 , A61K38/37
Abstract: The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.
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公开(公告)号：US11634504B2
公开(公告)日：2023-04-25
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20170073428A1
公开(公告)日：2017-03-16
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
Abstract translation: 本发明涉及特异性结合TFPI并抑制其活性的抗体及其抗原结合片段。 这样的抗体和片段可用于治疗出血性疾病和缩短凝血时间。
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公开(公告)号：US12168698B2
公开(公告)日：2024-12-17
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/00 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20210101998A1
公开(公告)日：2021-04-08
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K39/395 , A61K38/48
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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