公开(公告)号：US20170233368A1

公开(公告)日：2017-08-17

申请号：US15585880

申请日：2017-05-03

Applicant: Pfizer Inc.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  lndrawan James MCALPINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond ZEHNDER

IPC: C07D401/06 ,  C07D487/04 ,  C07D405/14 ,  C07D471/04 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20220306641A1

公开(公告)日：2022-09-29

申请号：US17693197

申请日：2022-03-11

Applicant: PFIZER INC.

Inventor： Ketan Satish GAJIWALA ,  Chan Woo HUH ,  Mehran JALAIE ,  Ryan Lloyd PATMAN ,  Eugene Yuanjin RUI ,  Jianmin SUN ,  Martin James WYTHES

IPC: C07D487/04 ,  C07D471/04

Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20150175572A1

公开(公告)日：2015-06-25

申请号：US14642274

申请日：2015-03-09

Applicant: PFIZER INC.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  Indrawan James MCALPINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond ZEHNDER

IPC: C07D401/06 ,  C07D471/04 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。

公开(公告)号：US20210087180A1

公开(公告)日：2021-03-25

申请号：US17029557

申请日：2020-09-23

Applicant: PFIZER INC.

Inventor： Ryan PATMAN ,  Martin James WYTHES ,  Eugene Yuanjin RUI ,  Indrawan James MCALPINE ,  Andrew FENSOME ,  Mehran JALAIE ,  Ketan S. GAJIWALA ,  Chan Woo HUH ,  Tuan Phong TRAN ,  Lei ZHANG ,  Dahui ZHOU ,  Ethan Lawrence FISHER

IPC: C07D403/14 ,  A61K31/4196 ,  C07D417/14 ,  A61K31/427 ,  A61K31/437 ,  C07D471/04 ,  C07D401/14 ,  A61K31/454 ,  A61K31/5386 ,  A61K31/5377 ,  C07D413/14 ,  C07D498/08 ,  C07D498/04 ,  A61K31/424 ,  C07D487/06 ,  C07D491/107 ,  C07D491/08 ,  A61K47/68 ,  A61K39/395 ,  A61K38/21

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20140179667A1

公开(公告)日：2014-06-26

申请号：US14132567

申请日：2013-12-18

Applicant: PFIZER INC.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  Indrawan James MCAPLINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond Zehnder

IPC: C07D401/06 ,  C07D487/04 ,  C07D401/14 ,  C07D471/04 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义的通式（I）化合物及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物来治疗异常细胞生长（包括癌症）的方法。

公开(公告)号：US20240383903A1

公开(公告)日：2024-11-21

申请号：US18608816

申请日：2024-03-18

Applicant: PFIZER INC.

Inventor： Ketan Satish GAJIWALA ,  Chan Woo HUH ,  Mehran JALAIE ,  Ryan Lloyd PATMAN ,  Eugene Yuanjin RUI ,  Jianmin SUN ,  Martin James WYTHES

IPC: C07D487/04 ,  C07D471/04

Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20230382932A1

公开(公告)日：2023-11-30

申请号：US18225589

申请日：2023-07-24

Applicant: PFIZER INC.

Inventor： Martin James WYTHES ,  Indrawan James MCALPINE ,  Ryan PATMAN ,  Eugene Yuanjin RUI ,  Andrew FENSOME ,  Andreas MADERNA ,  Mehran JALAIE ,  Ketan S. GAJIWALA

IPC: C07F9/6574 ,  A61K47/68 ,  A61P35/00 ,  C07H19/213

CPC classification number: C07F9/65744 ,  A61K47/6801 ,  A61P35/00 ,  C07H19/213

Abstract: Compounds of the general formula (I):




or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20170152239A1

公开(公告)日：2017-06-01

申请号：US15425732

申请日：2017-02-06

Applicant: PFIZER INC.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  Indrawan James MCALPINE ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES

IPC: C07D401/14 ,  C07D487/08 ,  C07D409/14 ,  C07D413/14 ,  C07D491/08 ,  C07D213/64 ,  C07D401/12 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D213/64 ,  C07D401/12 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/08

Abstract: This invention relates to compounds of general formula in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.