公开(公告)号：US20170233368A1

公开(公告)日：2017-08-17

申请号：US15585880

申请日：2017-05-03

Applicant: Pfizer Inc.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  lndrawan James MCALPINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond ZEHNDER

IPC: C07D401/06 ,  C07D487/04 ,  C07D405/14 ,  C07D471/04 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.