公开(公告)号：US20150175572A1

公开(公告)日：2015-06-25

申请号：US14642274

申请日：2015-03-09

Applicant: PFIZER INC.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  Indrawan James MCALPINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond ZEHNDER

IPC: C07D401/06 ,  C07D471/04 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。

公开(公告)号：US20170233368A1

公开(公告)日：2017-08-17

申请号：US15585880

申请日：2017-05-03

Applicant: Pfizer Inc.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  lndrawan James MCALPINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond ZEHNDER

IPC: C07D401/06 ,  C07D487/04 ,  C07D405/14 ,  C07D471/04 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20240294506A1

公开(公告)日：2024-09-05

申请号：US18346933

申请日：2023-07-05

Applicant: PFIZER INC.

Inventor： Douglas Carl BEHENNA ,  Kevin Daniel FREEMAN-COOK ,  Robert Louis HOFFMAN ,  Asako NAGATA ,  Sacha NINKOVIC ,  Scott Channing SUTTON

IPC: C07D403/12 ,  A61P35/00 ,  C07D413/12

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D413/12 ,  C07B2200/07

Abstract: This invention relates to compounds of Formula (I)






and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

公开(公告)号：US20140179667A1

公开(公告)日：2014-06-26

申请号：US14132567

申请日：2013-12-18

Applicant: PFIZER INC.

Inventor： Martin Paul EDWARDS ,  Robert Arnold KUMPF ,  Pei-Pei KUNG ,  Indrawan James MCAPLINE ,  Sacha NINKOVIC ,  Eugene Yuanjin RUI ,  Scott Channing SUTTON ,  John Howard TATLOCK ,  Martin James WYTHES ,  Luke Raymond Zehnder

IPC: C07D401/06 ,  C07D487/04 ,  C07D401/14 ,  C07D471/04 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义的通式（I）化合物及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物来治疗异常细胞生长（包括癌症）的方法。