公开(公告)号：US20240189410A1

公开(公告)日：2024-06-13

申请号：US18535116

申请日：2023-12-11

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Marina A. Gonzalez-Garis ,  Lei Hu ,  Isis Kanevsky ,  Paul Arthur Liberator ,  Justin Keith Moran ,  Lynn Marie Phelan ,  Michael William Pride ,  Shuai Shi ,  Naveen Surendran

IPC: A61K39/08 ,  A61K39/39 ,  A61P31/04

CPC classification number: A61K39/08 ,  A61K39/39 ,  A61P31/04 ,  A61K2039/55561

Abstract: The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.