公开(公告)号：US20230218735A1

公开(公告)日：2023-07-13

申请号：US18001953

申请日：2021-06-17

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Alexey Vyacheslavovitch Gribenko ,  William Carl Gruber ,  Kathrin Ute Jansen ,  Lakshmi Khandke ,  Nicholas Randolph Everard Kitchin ,  Jody Lawrence ,  Yahong Peng ,  Michael William Pride ,  Christopher Frederick Webber ,  Sabine Susanne Wellnitz ,  Zhuobiao Yi

IPC: A61K39/08 ,  A61K47/26 ,  A61K9/19 ,  C07K16/12 ,  A61P31/04

CPC classification number: A61K39/08 ,  A61K47/26 ,  A61K9/19 ,  C07K16/1282 ,  A61P31/04 ,  A61K2039/55577

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a Clostridium difficile toxoid A and/or a C. difficile toxoid B, and methods of use thereof. In another aspect, the invention relates to a method for eliciting an immune response in a human against a C. difficile infection. The method includes administering to the human an effective dose of a composition, which includes a C. difficile toxoid, wherein the composition is administered at least two times, and wherein the immune response against C. difficile toxin A and/or toxin B is sustained.