公开(公告)号：US20240252614A1

公开(公告)日：2024-08-01

申请号：US18413734

申请日：2024-01-16

Applicant: Pfizer Inc.

Inventor： Damon Andrew Hollands Berman ,  Ye Che ,  Alexey Vyacheslavovitch Gribenko ,  Bridget Yih Jiin Huang ,  Weiqiang Li ,  Yan Li ,  Kena Anne Swanson ,  Helen Chen Wang ,  Sabine Susanne Wellnitz ,  Kam Ho Wong ,  Qi Yang ,  Aiping Zhu

IPC: A61K39/155 ,  A61K9/51 ,  A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C07K16/10

CPC classification number: A61K39/155 ,  A61K9/5123 ,  A61K39/12 ,  C07K14/005 ,  C07K16/10 ,  A61K2039/70

Abstract: The present disclosure relates to hMPV F, PIV3 F and PIV1 F protein mutants, nucleic acids or vectors encoding a hMPV F, PIV3 F and PIV1 F protein mutant, compositions comprising a hMPV F, PIV3 F and PIV1 F protein mutant or nucleic acid, and uses of the hMPV F, PIV3 F and PIV1 F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：US20230218735A1

公开(公告)日：2023-07-13

申请号：US18001953

申请日：2021-06-17

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Alexey Vyacheslavovitch Gribenko ,  William Carl Gruber ,  Kathrin Ute Jansen ,  Lakshmi Khandke ,  Nicholas Randolph Everard Kitchin ,  Jody Lawrence ,  Yahong Peng ,  Michael William Pride ,  Christopher Frederick Webber ,  Sabine Susanne Wellnitz ,  Zhuobiao Yi

IPC: A61K39/08 ,  A61K47/26 ,  A61K9/19 ,  C07K16/12 ,  A61P31/04

CPC classification number: A61K39/08 ,  A61K47/26 ,  A61K9/19 ,  C07K16/1282 ,  A61P31/04 ,  A61K2039/55577

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a Clostridium difficile toxoid A and/or a C. difficile toxoid B, and methods of use thereof. In another aspect, the invention relates to a method for eliciting an immune response in a human against a C. difficile infection. The method includes administering to the human an effective dose of a composition, which includes a C. difficile toxoid, wherein the composition is administered at least two times, and wherein the immune response against C. difficile toxin A and/or toxin B is sustained.

公开(公告)号：US20220160859A1

公开(公告)日：2022-05-26

申请号：US17594107

申请日：2020-03-30

Applicant: Pfizer Inc.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Alexey Vyacheslavovitch Gribenko ,  Nicholas Randolph Everard Kitchin ,  Paul Liberator ,  Michael William Pride ,  Christopher Frederick Webber

IPC: A61K39/08 ,  A61P31/04 ,  C07K14/33 ,  C07K16/12

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a Clostridium difficile toxoid A and/or a C. difficile toxoid B, and methods of use thereof. In another aspect, the invention relates to a method for eliciting an immune response in a human against a C. difficile infection. The method includes administering to the human an effective dose of a composition, which includes a C. difficile toxoid, wherein the composition is administered at least two times, and wherein the immune response against C. difficile toxin A and/or toxin B is sustained.