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    Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
    4.
    发明授权
    Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors 失效
    CCK-B /胃泌素受体的免疫原性组合物和治疗肿瘤的方法

    公开(公告)号：US06548066B1

    公开(公告)日：2003-04-15

    申请号：US09076372

    申请日：1998-05-12

    申请人： Dov Michaeli ,  Martyn Caplin ,  Susan A. Watson ,  Stephen Grimes

    发明人： Dov Michaeli ,  Martyn Caplin ,  Susan A. Watson ,  Stephen Grimes

    IPC分类号： A61K39385

    CPC分类号： C07K14/72 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/0011 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K16/2869 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/77 ,  G01N33/57488

    摘要： The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.

    摘要翻译： 本发明涉及用于治疗胃泌素依赖性肿瘤的免疫原，免疫原性组合物和方法。 免疫原包含与间隔基缀合的CCK-B /胃泌素受体的肽和免疫原性载体。 免疫原能够在体内诱导结合肿瘤细胞中的CCK-B /胃泌素受体的抗体，从而防止生长刺激肽激素与受体结合并抑制肿瘤细胞生长。 免疫原还包括针对被动免疫的CCK-B /胃泌素受体的抗体。 本发明还涉及使用本发明的抗体在体内或组织活组织检查中检测胃泌素依赖性肿瘤的诊断方法。