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公开(公告)号：US06359114B1
公开(公告)日：2002-03-19
申请号：US08484740
申请日：1995-06-07
IPC分类号： C07K114
CPC分类号： B01D61/145 , B01J19/0046 , B01J2219/00283 , B01J2219/00355 , B01J2219/00479 , B01J2219/00725 , C07K1/02 , C07K1/34 , C40B40/10 , C40B60/14
摘要： A system is described for conjugating, isolating, and purifying proteins. The system contains an ultrafiltration apparatus which is connected with a reaction vessel reservoir.
摘要翻译： 描述了用于共轭，分离和纯化蛋白质的系统。 该系统包含与反应容器储存器连接的超滤装置。
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2.发明授权Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease 失效用于治疗和预防胃和十二指肠溃疡疾病的免疫原性组合物和方法
公开(公告)号：US5622702A
公开(公告)日：1997-04-22
申请号：US219773
申请日：1994-03-30
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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3.发明授权Method for immunization against and treatment of infection by ectoparasites and endoparasites 失效免疫接种和治疗外寄生虫和内寄生虫感染的方法
公开(公告)号：US4814170A
公开(公告)日：1989-03-21
申请号：US839892
申请日：1986-03-14
申请人： Stephen L. Karr, Jr.
发明人： Stephen L. Karr, Jr.
CPC分类号： A61K47/4833 , A61K39/0003 , A61K39/44 , A61K2039/6081
摘要： This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies formed to said immunogen.
摘要翻译： 本发明涉及一种针对外寄生虫和内寄生虫的脊椎动物的主动或被动免疫的方法，以及一种治疗由外寄生虫或内寄生虫感染的脊椎动物宿主的方法，包括向脊椎动物施用包含一种或多种外寄生物的内分泌产物的免疫原和 再加上免疫原性载体，或向脊椎动物施用形成于所述免疫原的单克隆抗体。
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公开(公告)号：US20090191232A1
公开(公告)日：2009-07-30
申请号：US12313969
申请日：2008-11-25
CPC分类号： A61K45/06 , A61K39/0011 , A61K2039/6037 , A61K2300/00
摘要： The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.
摘要翻译： 本发明涉及治疗胃泌素依赖性肿瘤的联合治疗方法。 该方法包括与给予化疗剂如5-氟尿嘧啶和甲酰四氢叶酸一起免疫具有抗胃泌素17免疫原性组合物的患者。
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公开(公告)号：US06861510B1
公开(公告)日：2005-03-01
申请号：US08465917
申请日：1995-06-06
IPC分类号： A61K39/00 , C07K14/595 , C07K16/26 , C07K16/00 , A61K39/395 , A61K39/40 , A61K39/42 , C12P21/08
CPC分类号： A61K39/0005 , A61K2039/6037 , A61K2039/627 , C07K14/595 , C07K16/26 , C07K2317/34 , C07K2317/73
摘要： Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
摘要翻译： 公开了可用于治疗其生长依赖于或由胃泌素激素刺激的溃疡或肿瘤的免疫组合物。 免疫原性组合物在受试者中诱导选择性中和特异性激素的抗体。 公开了包含有效量的免疫原性组合物和使用该组合物的治疗方法的药物组合物。 还公开了通过中和体内诱导的抗体来逆转本发明治疗的方法。
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公开(公告)号：US5866128A
公开(公告)日：1999-02-02
申请号：US465546
申请日：1995-06-05
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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7.发明授权Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin 失效用针对胃泌素的免疫原性组合物治疗胃肠道疾病的方法
公开(公告)号：US5785970A
公开(公告)日：1998-07-28
申请号：US462158
申请日：1995-06-05
IPC分类号： G01N33/53 , A61K38/00 , A61K38/22 , A61K39/00 , A61K39/395 , A61P1/04 , C07K5/113 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/595 , C07K16/00 , C07K16/26 , C07K19/00 , A61K39/385 , C07K5/00
CPC分类号： C07K16/26 , A61K39/0005 , A61K47/4833 , C07K14/595 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
摘要翻译： 公开了可用于治疗生长依赖于胃泌素激素或由胃泌素激素刺激的溃疡或肿瘤的免疫原性组合物。 免疫原性组合物在受试者中诱导选择性中和特定激素的抗体。 公开了包含有效量的免疫原性组合物和使用该组合物的治疗方法的药物组合物。 还公开了通过中和体内诱导的抗体来逆转本发明治疗的方法。
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公开(公告)号：US5609870A
公开(公告)日：1997-03-11
申请号：US285984
申请日：1994-08-04
IPC分类号： G01N33/53 , A61K38/00 , A61K38/22 , A61K39/00 , A61K39/395 , A61P1/04 , C07K5/113 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/595 , C07K16/00 , C07K16/26 , C07K19/00 , C07K5/00 , A61K39/385
CPC分类号： C07K16/26 , A61K39/0005 , A61K47/4833 , C07K14/595 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
摘要翻译： 公开了可用于治疗生长依赖于胃泌素激素或由胃泌素激素刺激的溃疡或肿瘤的免疫原性组合物。 免疫原性组合物在受试者中诱导选择性中和特定激素的抗体。 公开了包含有效量的免疫原性组合物和使用该组合物的治疗方法的药物组合物。 还公开了通过中和体内诱导的抗体来逆转本发明治疗的方法。
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公开(公告)号：US5607676A
公开(公告)日：1997-03-04
申请号：US721638
申请日：1991-07-22
IPC分类号： G01N33/53 , A61K38/00 , A61K38/22 , A61K39/00 , A61K39/395 , A61P1/04 , C07K5/113 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/595 , C07K16/00 , C07K16/26 , C07K19/00 , C07K5/00 , A61K39/385
CPC分类号： C07K16/26 , A61K39/0005 , A61K47/4833 , C07K14/595 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
摘要翻译： PCT No.PCT / US90 / 00520 Sec。 371日期1991年7月22日 102（e）日期1991年7月22日PCT 1990年1月23日PCT PCT。 出版物WO90 / 08774 日期1990年8月9日公开了用于治疗其生长依赖于或由胃泌素激素刺激的溃疡或肿瘤的免疫原性组合物。 免疫原性组合物在受试者中诱导选择性中和特定激素的抗体。 公开了包含有效量的免疫原性组合物和使用该组合物的治疗方法的药物组合物。 还公开了通过中和体内诱导的抗体来逆转本发明治疗的方法。
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10.发明授权Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease 失效用于治疗和预防胃和十二指肠溃疡疾病的免疫原性组合物和方法
公开(公告)号：US5023077A
公开(公告)日：1991-06-11
申请号：US301353
申请日：1989-01-24
IPC分类号： A61K39/00 , C07K14/595 , C07K16/26
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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