公开(公告)号：US06670372B2

公开(公告)日：2003-12-30

申请号：US10013202

申请日：2001-12-06

申请人： Leslie J. Charles ,  Joseph F. Dellaria ,  Philip D. Heppner ,  Bryon A. Merrill ,  John W. Mickelson

发明人： Leslie J. Charles ,  Joseph F. Dellaria ,  Philip D. Heppner ,  Bryon A. Merrill ,  John W. Mickelson

IPC分类号： A61K314745

CPC分类号： C07D471/04 ,  A61K31/4745 ,  Y02A50/409

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06989389B2

公开(公告)日：2006-01-24

申请号：US10696108

申请日：2003-10-29

申请人： Philip D. Heppner ,  Leslie J. Charles ,  Joseph F. Dellaria ,  Bryon A. Merrill ,  John W. Mickelson

发明人： Philip D. Heppner ,  Leslie J. Charles ,  Joseph F. Dellaria ,  Bryon A. Merrill ,  John W. Mickelson

IPC分类号： A61K31/4745 ,  C07D471/04 ,  A61P37/02 ,  A61P31/12

CPC分类号： C07D471/04

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06677348B2

公开(公告)日：2004-01-13

申请号：US10165750

申请日：2002-06-07

申请人： Phillip D. Heppner ,  Leslie J. Charles ,  Joseph F. Dellaria ,  Bryon A. Merrill ,  John W. Mickelson

发明人： Phillip D. Heppner ,  Leslie J. Charles ,  Joseph F. Dellaria ,  Bryon A. Merrill ,  John W. Mickelson

IPC分类号： A61K314745

CPC分类号： C07D471/04

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06664260B2

公开(公告)日：2003-12-16

申请号：US10011921

申请日：2001-12-06

申请人： Leslie J. Charles ,  Joseph F. Dellaria ,  George W. Griesgraber ,  Philip D. Heppner ,  Karl J. Manske ,  John W. Mickelson ,  Michael J. Rice

发明人： Leslie J. Charles ,  Joseph F. Dellaria ,  George W. Griesgraber ,  Philip D. Heppner ,  Karl J. Manske ,  John W. Mickelson ,  Michael J. Rice

IPC分类号： A61K314745

CPC分类号： C07D471/04

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.