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公开(公告)号:US20050025770A1
公开(公告)日:2005-02-03
申请号:US10762226
申请日:2004-01-20
申请人: Philip Gevas , Stephen Karr , Stephen Grimes , Dov Michaeli , Susan Watson
发明人: Philip Gevas , Stephen Karr , Stephen Grimes , Dov Michaeli , Susan Watson
IPC分类号: A61K38/00 , A61K39/00 , C07K14/595 , C07K16/26 , A61K39/395
CPC分类号: C07K14/595 , A61K38/00 , A61K39/00 , C07K16/26 , C07K2317/732
摘要: A method of treating gastrointestinal cancers dependent on the prohormones amidated gastrin-17 and glycine extended G-17, comprising the administration to the patient of an anti-gastrin 17 immunogen which induces antibodies which bind and neutralize amidated and glycine-extended gastrin-17.
摘要翻译: 治疗胃肠癌的治疗方法,其依赖于酰化胃泌素-17和甘氨酸延伸的G-17的激素原,其包括向患者施用抗胃泌素17免疫原,其诱导结合并中和酰胺化和甘氨酸延长的胃泌素-17的抗体。
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公开(公告)号:US20050187152A1
公开(公告)日:2005-08-25
申请号:US10829137
申请日:2004-04-21
申请人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli , Susan Watson
发明人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli , Susan Watson
IPC分类号: A61K39/385 , A61K38/00 , A61K38/22 , A61K47/48 , A61P7/00 , A61P37/04 , C07K7/06 , C07K7/08 , C07K14/595 , C07K16/26 , C07K16/40 , A61K38/17 , A61K31/4172 , A61K31/4439
CPC分类号: C07K16/26 , A61K38/2207 , A61K47/643 , A61K2039/505 , C07K14/595 , C07K2317/34
摘要: Serum-associated hypergastrinemia is treated by administration of gastrin active or passive immunization. An anti-gastrin immunogenic composition containing a gastrin G17 or G34 peptide fragment which is amino acid spacer-linked to an immunogenic carrier, is administered so as to effectively neutralize the circulating gastrin hormone, and moreover, inhibit autocrine activity by progastrin such as Gly-extended G17, and amidated G17, in patients with pernicious anemia. Moreover, the method includes administration of a therapeutically effective amount of anti-G17 or anti-G34 antibodies which may be in humanized form. Finally, the method provides ameliorating treatment of hypergastrinemic effects of proton pump inhibitors or H2 histamine receptor blocking agents or antagonists, in addition to treatment of hypergastrinemia caused by diseases such as pernicious anemia.
摘要翻译: 通过施用胃泌素活性或被动免疫来治疗血清相关性高胃泌素血症。 给予含有与免疫原性载体间隔连接的氨基酸的胃泌素G17或G34肽片段的抗胃泌素免疫原性组合物,以有效中和循环的胃泌素激素,此外,抑制前胃泌素如Gly- 延长G17,并与G17阴性,患有恶性贫血患者。 此外,该方法包括施用治疗有效量的可以以人源化形式存在的抗G17或抗G34抗体。 最后,除了治疗由诸如恶性贫血等疾病引起的胃泌素血症外,该方法还提供改善质子泵抑制剂或H 2 H 2组胺受体阻断剂或拮抗剂的高胃肠道作用的改善。
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公开(公告)号:US20060039911A1
公开(公告)日:2006-02-23
申请号:US11252904
申请日:2005-10-18
申请人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli
发明人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli
IPC分类号: A61K39/395 , A61K38/22
CPC分类号: A61K39/0005 , A61K38/2207 , A61K2039/6037 , A61K2300/00
摘要: A method for the treatment of gastroesophageal reflux disease comprising a combination of active immunization with an anti-gastrin immunogenic composition with an antagonist that blocks or inhibits gastric acid pump activity; or alternatively administering purified anti-gastrin antibodies with an H2 antagonist or proton pump inhibitor of the gastric acid producing enzyme system.
摘要翻译: 一种治疗胃食管反流病的方法,包括主动免疫与抗胃泌素免疫原性组合物与阻断或抑制胃酸泵活性的拮抗剂的组合; 或者另外用产生胃酸的酶系统的H 2拮抗剂或质子泵抑制剂给予纯化的抗胃泌素抗体。
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公开(公告)号:US20060140962A1
公开(公告)日:2006-06-29
申请号:US11360378
申请日:2006-02-22
申请人: Philip Gevas , Dov Michaeli , Stephen Grimes , Martyn Caplin
发明人: Philip Gevas , Dov Michaeli , Stephen Grimes , Martyn Caplin
IPC分类号: A61K39/395 , A61K31/4745
CPC分类号: A61K39/0011 , A61K39/0005 , A61K2039/505 , A61K2039/6037 , C07K16/26
摘要: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
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5.
公开(公告)号:US4795634A
公开(公告)日:1989-01-03
申请号:US839894
申请日:1986-03-14
申请人: Stephen Grimes , Elizer Benjamini , Philip Gevas
发明人: Stephen Grimes , Elizer Benjamini , Philip Gevas
CPC分类号: C07K16/28 , C07K16/4208 , Y10S424/811 , Y10S530/861 , Y10S530/864
摘要: This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.
摘要翻译: 本发明涉及一种避孕方法,其包括使用包含有效量的抗透明带抗体形成的抗独特型抗体的组合物对女性哺乳动物免受透明带的主动免疫,所述抗独特型抗体表达透明带的内部图像 能够诱发避孕反应的抗原决定簇。
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