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公开(公告)号:US20050025770A1
公开(公告)日:2005-02-03
申请号:US10762226
申请日:2004-01-20
申请人: Philip Gevas , Stephen Karr , Stephen Grimes , Dov Michaeli , Susan Watson
发明人: Philip Gevas , Stephen Karr , Stephen Grimes , Dov Michaeli , Susan Watson
IPC分类号: A61K38/00 , A61K39/00 , C07K14/595 , C07K16/26 , A61K39/395
CPC分类号: C07K14/595 , A61K38/00 , A61K39/00 , C07K16/26 , C07K2317/732
摘要: A method of treating gastrointestinal cancers dependent on the prohormones amidated gastrin-17 and glycine extended G-17, comprising the administration to the patient of an anti-gastrin 17 immunogen which induces antibodies which bind and neutralize amidated and glycine-extended gastrin-17.
摘要翻译: 治疗胃肠癌的治疗方法,其依赖于酰化胃泌素-17和甘氨酸延伸的G-17的激素原,其包括向患者施用抗胃泌素17免疫原,其诱导结合并中和酰胺化和甘氨酸延长的胃泌素-17的抗体。
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公开(公告)号:US20050187152A1
公开(公告)日:2005-08-25
申请号:US10829137
申请日:2004-04-21
申请人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli , Susan Watson
发明人: Philip Gevas , Stephen Grimes , Stephen Karr , Dov Michaeli , Susan Watson
IPC分类号: A61K39/385 , A61K38/00 , A61K38/22 , A61K47/48 , A61P7/00 , A61P37/04 , C07K7/06 , C07K7/08 , C07K14/595 , C07K16/26 , C07K16/40 , A61K38/17 , A61K31/4172 , A61K31/4439
CPC分类号: C07K16/26 , A61K38/2207 , A61K47/643 , A61K2039/505 , C07K14/595 , C07K2317/34
摘要: Serum-associated hypergastrinemia is treated by administration of gastrin active or passive immunization. An anti-gastrin immunogenic composition containing a gastrin G17 or G34 peptide fragment which is amino acid spacer-linked to an immunogenic carrier, is administered so as to effectively neutralize the circulating gastrin hormone, and moreover, inhibit autocrine activity by progastrin such as Gly-extended G17, and amidated G17, in patients with pernicious anemia. Moreover, the method includes administration of a therapeutically effective amount of anti-G17 or anti-G34 antibodies which may be in humanized form. Finally, the method provides ameliorating treatment of hypergastrinemic effects of proton pump inhibitors or H2 histamine receptor blocking agents or antagonists, in addition to treatment of hypergastrinemia caused by diseases such as pernicious anemia.
摘要翻译: 通过施用胃泌素活性或被动免疫来治疗血清相关性高胃泌素血症。 给予含有与免疫原性载体间隔连接的氨基酸的胃泌素G17或G34肽片段的抗胃泌素免疫原性组合物,以有效中和循环的胃泌素激素,此外,抑制前胃泌素如Gly- 延长G17,并与G17阴性,患有恶性贫血患者。 此外,该方法包括施用治疗有效量的可以以人源化形式存在的抗G17或抗G34抗体。 最后,除了治疗由诸如恶性贫血等疾病引起的胃泌素血症外,该方法还提供改善质子泵抑制剂或H 2 H 2组胺受体阻断剂或拮抗剂的高胃肠道作用的改善。
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公开(公告)号:US06794130B2
公开(公告)日:2004-09-21
申请号:US09171847
申请日:1999-03-11
IPC分类号: C12Q168
CPC分类号: C12Q1/6806 , C12N15/1006
摘要: Nucleic acid is captured from a mixture of cellular debris produced by cell lysis by exposing the mixture to an electrode and applying a nucleic acid capturing voltage to the electrode which is then removed from the mixture carrying said nucleic acid. The nucleic acid is undamaged and can be amplified by PCR.
摘要翻译: 通过将混合物暴露于电极并将核酸捕获电压施加到电极上从细胞裂解产生的细胞碎片的混合物中捕获核酸,然后将其从携带所述核酸的混合物中除去。 核酸没有损伤,可以通过PCR扩增。
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