公开(公告)号：US07056722B1

公开(公告)日：2006-06-06

申请号：US09709237

申请日：2000-11-10

申请人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock

发明人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock

IPC分类号： C12N9/74 ,  C12Q1/56

CPC分类号： G01N33/86 ,  A61J3/002 ,  A61K35/16 ,  A61L24/108 ,  C12N9/6429 ,  C12Y304/21005 ,  G01N33/4905 ,  G01N2333/974

摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.

摘要翻译： 一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。 组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。 凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。 此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

公开(公告)号：US06472162B1

公开(公告)日：2002-10-29

申请号：US09328350

申请日：1999-06-04

申请人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock ,  Trista K. Madsen ,  Sona B. Frausto

发明人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock ,  Trista K. Madsen ,  Sona B. Frausto

IPC分类号： C12Q156

CPC分类号： C12N9/6429 ,  A61K38/4833 ,  C12Y304/21005

摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.

摘要翻译： 一种用于从单一供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分和凝血和粘附蛋白组分在少于1小时内从相同供体血浆同时收获。 组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。 凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。 此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

公开(公告)号：US06274090B1

公开(公告)日：2001-08-14

申请号：US09129988

申请日：1998-08-05

申请人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock

发明人： Philip Henry Coelho ,  Phil Kingsley ,  Jim Brausch ,  James H. Godsey ,  Gail Rock

IPC分类号： B01L1100

CPC分类号： G01N33/86 ,  A61J3/002 ,  A61K35/16 ,  A61L24/108 ,  C12N9/6429 ,  C12Y304/21005 ,  G01N33/4905 ,  G01N2333/974

摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.

摘要翻译： 一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。 组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。 凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。 此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

公开(公告)号：US07182107B2

公开(公告)日：2007-02-27

申请号：US10737066

申请日：2003-12-15

申请人： Eric Sommer ,  Philip Henry Coelho ,  Phil Kingsley

发明人： Eric Sommer ,  Philip Henry Coelho ,  Phil Kingsley

IPC分类号： B65B1/04

CPC分类号： A61B17/00491 ,  A61B2017/00495

摘要： A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.

摘要翻译： 具有用于将注射器对与凝血酶和粘合剂一起加载并用于生物粘合剂的凝血蛋白的分配歧管的装载站。 所得到的装载的注射器对与各种生物粘合剂分配器兼容，并且可以用于手术设置。

公开(公告)号：US06679300B1

公开(公告)日：2004-01-20

申请号：US10050225

申请日：2002-01-14

申请人： Eric Sommer ,  Philip Henry Coelho ,  Phil Kingsley

发明人： Eric Sommer ,  Philip Henry Coelho ,  Phil Kingsley

IPC分类号： B65B104

CPC分类号： A61B17/00491 ,  A61B2017/00495

摘要： A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.