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    Method for the preparation of macromolecularized adenine derivatives
    1.
    发明授权
    Method for the preparation of macromolecularized adenine derivatives 失效
    高分子量腺嘌呤衍生物的制备方法

    公开(公告)号：US4336188A

    公开(公告)日：1982-06-22

    申请号：US880133

    申请日：1978-02-22

    申请人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    发明人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    IPC分类号： C08F8/00 ,  C07D473/34 ,  C07H19/167 ,  C08B11/20 ,  C08F8/34 ,  C08G73/00 ,  C08G85/00 ,  C12N11/04 ,  C07H19/20

    CPC分类号： C07D473/34

    摘要： A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formula M.sup.+- S--(CH.sub.2).sub.n --COO.sup.- M.sup.+ wherein M.sup.+ is the ion of an alkali metal and n is an integer, the reaction being carried out in a polar aprotic solvent. Procedures for preparing macromolecularized adenine compounds are also indicated by reacting a functionalized adenine derivative with a polymer which has at least one primary or secondary aminic group in its structure. This is a division of application Ser. No. 705,012 filed July 14, 1976, U.S. Pat. No. 4,091,203.

    摘要翻译： 公开了一种制备官能化腺嘌呤衍生物的方法，所述方法包括使含有在8-位被卤素取代的腺嘌呤核的化合物与具有通式M + -S-（CH 2）n的化合物反应的步骤 -COO-M +其中M +是碱金属的离子，n是整数，反应在极性非质子溶剂中进行。 制备高分子量腺嘌呤化合物的方法也通过官能化腺嘌呤衍生物与其结构中具有至少一个伯或仲氨基的聚合物反应来表示。 这是一个应用程序系列 1976年7月14日提交的美国专利号705,012， 4,091,203。

    Macromolecularized adenine derivatives
    2.
    发明授权
    Macromolecularized adenine derivatives 失效
    大分子腺嘌呤衍生物

    公开(公告)号：US4199498A

    公开(公告)日：1980-04-22

    申请号：US880290

    申请日：1978-02-22

    申请人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    发明人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    IPC分类号： C07D473/34 ,  C07H19/20 ,  C07C103/52

    CPC分类号： C07D473/34

    摘要： A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formula N.sup.+- S--(CH.sub.2).sub.n --CO0.sup.- M.sup.+ wherein M.sup.+ is the ion of an alkali metal and n is an integer, the reaction being carried out in a polar aprotic solvent. Procedures for preparing macromolecularized adenine compounds are also indicated by reacting a functionalized adenine derivative with a polymer which has at least one primary or secondary aminic group in its structure.

    摘要翻译： 公开了制备官能化腺嘌呤衍生物的方法，所述方法包括使含有在8-位被卤素取代的腺嘌呤核的化合物与具有通式N + -S-（CH 2）n的化合物反应的步骤 -COO-M +，其中M +是碱金属的离子，n是整数，反应在极性非质子溶剂中进行。 制备高分子量腺嘌呤化合物的方法也通过官能化腺嘌呤衍生物与其结构中具有至少一个伯或仲氨基的聚合物反应来表示。

    Adenine derivatives
    3.
    发明授权
    Adenine derivatives 失效
    腺嘌呤衍生物

    公开(公告)号：US4091203A

    公开(公告)日：1978-05-23

    申请号：US705012

    申请日：1976-07-14

    申请人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    发明人： Piergiorgio Zappelli ,  Antonio Rossodivita ,  Rosario Pappa ,  Luciano Re

    IPC分类号： C08F8/00 ,  C07D473/34 ,  C07H19/167 ,  C08B11/20 ,  C08F8/34 ,  C08G73/00 ,  C08G85/00 ,  C12N11/04 ,  C07H19/16

    CPC分类号： C07D473/34

    摘要： A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formula M.sup.+- S--(CH.sub.2).sub.n --COO.sup.- M.sup.+ wherein M.sup.+ is the ion of an alkali metal and n is an integer, the reaction being carried out in a polar aprotic solvent. Procedures for preparing macromolecularized adenine compounds are also indicated by reacting a functionalized adenine derivative with a polymer which has at least one primary or secondary aminic group in its structure.

    摘要翻译： 公开了一种制备官能化腺嘌呤衍生物的方法，所述方法包括使含有在8-位被卤素取代的腺嘌呤核的化合物与具有通式M + -S-（CH 2）n的化合物反应的步骤 -COO-M +其中M +是碱金属的离子，n是整数，反应在极性非质子溶剂中进行。 制备高分子量腺嘌呤化合物的方法也通过官能化腺嘌呤衍生物与其结构中具有至少一个伯或仲氨基的聚合物反应来表示。

    Tetravalent metal diphosphonate-phosphite composition in microporous solid crystalline form, with a narrow micropore distribution
    4.
    发明授权
    Tetravalent metal diphosphonate-phosphite composition in microporous solid crystalline form, with a narrow micropore distribution 失效
    四价金属二膦酸盐 - 亚磷酸盐组合物为微孔固体晶型，具有窄的微孔分布

    公开(公告)号：US5290746A

    公开(公告)日：1994-03-01

    申请号：US809587

    申请日：1991-12-17

    申请人： Giulio Alberti ,  Umberto Costantino ,  Riccardo Vivani ,  Piergiorgio Zappelli ,  Antonio Rossodivita

    发明人： Giulio Alberti ,  Umberto Costantino ,  Riccardo Vivani ,  Piergiorgio Zappelli ,  Antonio Rossodivita

    IPC分类号： C07F9/38 ,  C07F7/00

    CPC分类号： C07F9/3843 ,  C07F9/386

    摘要： A tetravalent metal diphosphonate-phosphite composition definable by the following general formula:M(O.sub.3 P--R--PO.sub.3).sub.1-x (HPO.sub.3).sub.2x (I)is described where:M is a tetravalent metal;x varies from 0.5 to 0.66;R is an organic radical of bivalent aromatic type, carrying side groups which increase its steric hindrance.The composition is in the form of a crystalline solid with a type .alpha. layered structure with the diphosphonic groups positioned to join said layers together by a covalent bond (pillared compounds). It has a B.E.T. surface area from 300 to 500 m.sup.2 /g depending on the nature of R in formula (I), and a porosity in the micropore radius range of less than 20 .ANG. (Angstrom), such micropores contributing to the extent of more than 95% of the total area for the most crystalline materials.

    摘要翻译： 描述了通过以下通式可定义的四价金属二膦酸盐 - 亚磷酸盐组合物：M（O3P-R-PO3）1-x（HPO3）2x（I），其中：M是四价金属; x从0.5变化到0.66; R是二价芳族类型的有机基团，带有增加其空间位阻的侧基。 组合物是具有类型（α）层状结构的结晶固体的形式，其中二膦基定位为通过共价键（柱状化合物）将所述层连接在一起。 它有一个B.E.T. 取决于式（I）中R的性质以及微孔半径范围小于20（Aangstroem）（埃）的孔隙率，表面积为300-500m2 / g，这种微孔有助于超过95 最大结晶材料总面积的百分比。

    Mesoporous crystalline solid compound of a diphosphonate/phosphite of a tetravalent metal, with a narrow distribution of mesopores
    5.
    发明授权
    Mesoporous crystalline solid compound of a diphosphonate/phosphite of a tetravalent metal, with a narrow distribution of mesopores 失效
    两相金属的二磷酸盐/磷酸盐的多孔结晶固体化合物，具有MESOPORES的窄幅分布

    公开(公告)号：US5166380A

    公开(公告)日：1992-11-24

    申请号：US738891

    申请日：1991-08-01

    申请人： Giulio Alberti ,  Umberto Costantino ,  Riccardo Vivani ,  Piergiorgio Zappelli ,  Antonio Rossodivita ,  Luciano Bassignani

    发明人： Giulio Alberti ,  Umberto Costantino ,  Riccardo Vivani ,  Piergiorgio Zappelli ,  Antonio Rossodivita ,  Luciano Bassignani

    IPC分类号： C07F9/40 ,  B01J20/02 ,  B01J29/03 ,  B01J29/04 ,  C07F7/00 ,  C07F9/02 ,  C07F9/38

    CPC分类号： C07F9/3843 ,  B01J20/223 ,  B01J29/049 ,  C07F9/02

    摘要： The present invention discloses a compound comprising a diphosphonate/phosphite of a tetravalent metal:M[(O.sub.3 P--R--PO.sub.3).sub.1-(x+y) (HPO.sub.3).sub.2X (O.sub.3 P--R--PO.sub.3 H.sub.2).sub.2y ](where M, R, x and y have the meaning given in the description), in the form of a crystalline solid with an alpha-type lamellar structure with a distance between layers of 7.4 to 20.ANG. (depending on the dimensions of radical R), a BET surface area of 250 to 400m.sup.2 /g, and porosity within the mesopore range, with at least 50% of the pores measuring 20 to 30.ANG.. The compound, depending on the radical R used, may or may not have microporosity in the region between layers. Such a diphosphonate/phosphite of a tetravalent metal is obtained by reaction between diphosphonic acid, phosphorous acid and an oxyhalide of a tetravalent metal, in a solvent comprising dimethyl-sulphoxide/water containing hydrofluoric acid.

    摘要翻译： 本发明公开了包含四价金属的二膦酸盐/亚磷酸盐的化合物：M [（O3P-R-PO3）1-（x + y）（HPO3）2X（O3P-R-PO3H2）2y]（其中M，R ，x和y具有在描述中给出的含义），具有α层型结构的结晶固体形式，层间距离为7.4至20安培（取决于基团R的尺寸），BET表面 面积为250〜400m2 / g，孔隙度在中孔范围内，孔中至少有50％为20〜30 ANGSTROM。 取决于所使用的基团R的化合物在层之间的区域中可能具有或可以不具有微孔性。 在包含二甲基亚砜/含有氢氟酸的水的溶剂中，通过二膦酸，亚磷酸和四价金属的卤氧化物之间的反应获得四价金属的二膦酸盐/亚磷酸酯。

    Process for the preparation of adenine derivatives made functional and products obtained therefrom
    7.
    发明授权
    Process for the preparation of adenine derivatives made functional and products obtained therefrom 失效
    制备腺嘌呤衍生物的方法具有功能性及其产物

    公开(公告)号：US4008363A

    公开(公告)日：1977-02-15

    申请号：US572653

    申请日：1975-04-29

    申请人： Luciano Re ,  Piergiorgio Zappelli

    发明人： Luciano Re ,  Piergiorgio Zappelli

    IPC分类号： C07D473/34 ,  C07D303/48 ,  C07F9/6561 ,  C07H19/207 ,  C07H19/20

    CPC分类号： C07H19/207 ,  C07D303/48 ,  C07F9/65616

    摘要： Nicotinamide 6-(2-hydroxy-3-carboxy-propylamino) purine dinucleotide is prepared by reacting nicotinamide-adenine-dinucleotide with 3,4 epoxybutanoic acid in the presence of perchloric acid to prepare an intermediate wherein the adenine nucleus is alkylated in the N.sub.1 position. That intermediate is subjected to chemical reduction of the nicotinamide ring, followed by rearrangement to yield the end product wherein the amino group in position 6 of the adenine ring is alkylated.

    摘要翻译： 烟酰胺6-（2-羟基-3-羧基 - 丙基氨基）嘌呤二核苷酸是通过在高氯酸存在下使烟酰胺 - 腺嘌呤二核苷酸与3,4环氧丁酸反应来制备中间体，其中腺嘌呤核在N1 位置。 对该中间体进行烟酰胺环的化学还原，然后重排以产生其中腺嘌呤环的位置6的氨基被烷基化的最终产物。