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1.发明授权Slimming cosmetic composition containing a substance inducing the production of IL-6 失效含有诱导产生IL-6的物质的减肥化妆品组合物公开(公告)号：US08628770B2
公开(公告)日：2014-01-14
申请号：US12259575
申请日：2008-10-28
IPC分类号： A61K35/66
CPC分类号： A61Q19/06 , A61K8/99 , A61K2800/70
摘要： This invention relates to a slimming cosmetic composition containing at least one compound inducing the production of IL-6 by the adipocytes in the form of a mixture with an NPY antagonist and/or an α2 antagonist and with an excipient for a cosmetic preparation.
摘要翻译： 本发明涉及一种减肥化妆品组合物，其含有至少一种诱导与NPY拮抗剂和/或α2拮抗剂混合形式的脂肪细胞产生IL-6的化合物和用于化妆品制剂的赋形剂。
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2.发明申请Slimming cosmetic composition containing a substance inducing the production of IL-6 审中-公开含有诱导产生IL-6的物质的减肥化妆品组合物公开(公告)号：US20050281895A1
公开(公告)日：2005-12-22
申请号：US11192845
申请日：2005-07-28
IPC分类号： A61K8/00 , A61K8/18 , A61K8/64 , A61K8/96 , A61K8/97 , A61K8/98 , A61K8/99 , A61K35/12 , A61K35/74 , A61K38/00 , A61K45/00 , A61P3/04 , A61Q19/00 , A61Q19/06 , A61Q90/00 , A61K35/78
CPC分类号： A61Q19/06 , A61K8/99 , A61K2800/70
摘要： This invention relates to a slimming cosmetic composition containing at least one compound inducing the production of IL-6 by the adipocytes in the form of a mixture with an NPY antagonist and/or an α2 antagonist and with an excipient for a cosmetic preparation.
摘要翻译： 本发明涉及一种减肥化妆品组合物，其含有至少一种诱导与NPY拮抗剂和/或α2拮抗剂的混合物形式的脂肪细胞产生IL-6的化合物和 赋形剂用于化妆品制剂。
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3.发明授权Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics 失效吡啶并吲哚酮衍生物在3位被杂环基取代，其制备及其在治疗中的应用公开(公告)号：US07456193B2
公开(公告)日：2008-11-25
申请号：US11109121
申请日：2005-04-19
IPC分类号： A61K31/437 , C07D487/04 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I): in which: R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 represents a hydrogen atom or a (C1-C4)alkyl group; R3 represents a thienyl mono- or polysubstituted by a methyl group; or a monocyclic or bicyclic heterocyclic radical chosen from: a pyridyl, an N-oxidopyridinio, a pyrazolyl, an (N-phenyl)pyrazolyl, an (N-halophenyl)pyrazolyl, a furyl, an indolyl, an (N-benzyl)indolyl, an (N-halobenzyl)indolyl, a benzothienyl or a benzofuryl, the said radicals being unsubstituted or substituted one or more times by a halogen atom or a methyl or methoxy group; R4 and R5 are identical or different and each independently represent a hydrogen or halogen atom or a hydroxyl, hydroxymethyl, (C1-C4)alkyl, trifluoromethyl, C1-C4)alkoxy, (C1-C4)alkoxycarbonyl or cyano group. Preparation process and application in therapeutics.
摘要翻译： 本发明涉及通式（I）的杂环基在3-位上取代的吡啶并吲哚酮衍生物：其中：R 1表示氢原子或（C 1〜 （C 1 -C 4）烷基; R 2表示氢原子或（C 1 -C 4 -C 4）烷基; R 3表示被甲基单取代或多取代的噻吩基; 或选自以下的单环或双环杂环基：吡啶基，N-氧化吡啶基，吡唑基，（N-苯基）吡唑基，（N-卤代苯基）吡唑基，呋喃基，吲哚基，（N-苄基）吲哚基 ，（N-卤代苄基）吲哚基，苯并噻吩基或苯并呋喃基，所述基团是未取代的或被卤素原子或甲基或甲氧基取代一次或多次; R 4和R 5相同或不同，并且各自独立地表示氢或卤素原子或羟基，羟甲基，（C 1 -C 3 - （C 1 -C 4）烷基，三氟甲基，C 1 -C 4烷氧基，（C 1 -C 4 - 4）烷氧基羰基或氰基。 制剂工艺及其在治疗中的应用
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4.发明申请公开(公告)号：US20050272760A1
公开(公告)日：2005-12-08
申请号：US11204275
申请日：2005-08-15
IPC分类号： A61K45/00 , A61K31/437 , A61K31/519 , A61K45/06 , A61P35/00 , A61P43/00 , C07D471/04 , A61K31/4745
CPC分类号： A61K31/437 , A61K31/435 , A61K45/06 , A61K2300/00
摘要： The invention relates to a novel use of compounds of formula: for the preparation of medicinal products that are useful as anticancer agents.
摘要翻译： 本发明涉及式的化合物的新用途：用于制备可用作抗癌剂的药用产品。
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5.发明授权Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents 有权基于吡啶并吲哚酮衍生物和抗癌剂的药物组合公开(公告)号：US07524857B2
公开(公告)日：2009-04-28
申请号：US10476321
申请日：2002-04-26
IPC分类号： A61K31/44
CPC分类号： A61K31/437 , A61K31/435 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combination of compounds of formula: with one or more anticancer agents.
摘要翻译： 本发明涉及下式化合物与一种或多种抗癌剂的组合。
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6.发明授权Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress 失效使用与外周苯并二氮杂受体结合的物质治疗皮肤压力公开(公告)号：US06767533B1
公开(公告)日：2004-07-27
申请号：US09831720
申请日：2001-05-14
申请人： Pierre Casellas , Jean-Marie Derocq
发明人： Pierre Casellas , Jean-Marie Derocq
IPC分类号： A61K742
CPC分类号： A61K31/5513 , A61K8/494 , A61K31/19 , A61K31/203 , A61K31/74 , A61K2800/70 , A61Q17/04 , A61Q19/00 , A61Q19/08 , Y10S435/803 , Y10S435/886 , Y10S514/828 , Y10S514/947
摘要： A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress.
摘要翻译： 含有用于局部用于治疗皮肤应激的外周苯并二氮杂受体配体的组合物。
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7.发明授权Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics 失效吡啶并吲哚酮衍生物在3位被杂环基取代，其制备及其在治疗中的应用公开(公告)号：US07816368B2
公开(公告)日：2010-10-19
申请号：US12252647
申请日：2008-10-16
IPC分类号： A61K31/44
CPC分类号： C07D471/04
摘要： The present disclosure relates to pyridoindolone derivatives of general formula (I): in which R1 to R5 are as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.
摘要翻译： 本公开涉及通式（I）的吡啶并吲哚酮衍生物：其中R 1至R 5如本说明书中所定义，用于制备所述衍生物的方法及其使用方法。
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8.发明授权Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics 有权吡啶并吲哚酮衍生物在3-位被苯基取代，其制备及其在治疗中的应用公开(公告)号：US08012991B2
公开(公告)日：2011-09-06
申请号：US12118920
申请日：2008-05-12
申请人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
发明人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.
摘要翻译： 本公开涉及通式（I）的吡啶并吲哚酮衍生物：其制备方法及其在治疗中的用途。
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9.发明申请Pyridoindolone Derivatives Substituted in the 3-Position by a Phenyl, Their Preparation and Their Application in Therapeutics 有权吡啶并吲哚酮衍生物在3-位被苯基取代，其制备及其在治疗中的应用公开(公告)号：US20080214538A1
公开(公告)日：2008-09-04
申请号：US12118920
申请日：2008-05-12
申请人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
发明人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
IPC分类号： A61K31/437 , A61P35/00 , C07D471/04 , A61K31/5377 , A61K31/506
CPC分类号： C07D471/04
摘要： The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.
摘要翻译： 本公开涉及通式（I）的吡啶并吲哚酮衍生物：其制备方法及其在治疗中的用途。
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10.发明申请Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics 有权吡啶并吲哚酮衍生物在3-位被苯基取代，其制备及其在治疗中的应用公开(公告)号：US20050288318A1
公开(公告)日：2005-12-29
申请号：US11109068
申请日：2005-04-19
申请人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
发明人： Bernard Bourrie , Pierre Casellas , Paola Ciapetti , Jean-Marie Derocq , Samir Jegham , Yvette Muneaux , Camille-Georges Wermuth
IPC分类号： A61K31/437 , A61K31/4745 , A61P35/00 , C07D20060101 , C07D209/00 , C07D221/00 , C07D239/00 , C07D471/02 , C07D471/04 , C07D471/16
CPC分类号： C07D471/04
摘要： The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I): to processes for preparing the same and to their use in therapeutics.
摘要翻译： 本发明涉及通过通式（I）的苯基在3-位上取代的吡啶并吲哚酮衍生物：其制备方法及其在治疗中的用途。
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