公开(公告)号：US5393430A

公开(公告)日：1995-02-28

申请号：US98095

申请日：1993-07-28

申请人： Pierre Girot ,  Eoisto Boschetti

发明人： Pierre Girot ,  Eoisto Boschetti

IPC分类号： B01D15/08 ,  B01J20/32 ,  B01J39/16

CPC分类号： B01D15/206 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/165 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

摘要： This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide supports are disclosed that are stabilized against leaching under harsh environmental conditions by the application of a thin, protective polymeric coating atop their porous surfaces and that are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by the use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction between biomolecules and the protective polymeric coating on the surfaces of the mineral oxide matrix.

摘要翻译： 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔无机氧化物载体，其在恶劣的环境条件下通过在其多孔表面顶上施加薄的保护性聚合物涂层而稳定化，并且其特征在于基本上不伴随非特异性吸附的可逆的高吸附能力 或与生物分子相互作用。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除生物分子与生物分子之间不合需要的非特异性相互作用 矿物氧化物基体表面上的保护性聚合物涂层。