NOVEL SMALL MOLECULES FOR TARGETED DEGRADATION OF UNTARGETABLE KRAS IN CANCER THERAPY

    公开(公告)号:US20230202981A1

    公开(公告)日:2023-06-29

    申请号:US18008332

    申请日:2021-05-26

    摘要: The present invention discloses novel anti-cancer activity exhibiting compounds for treating subjects with chronic disorder, comprising of structure in accordance with Formula 1 or any derivative thereof, or a stereoisomer or tautomer thereof, pharmaceutically acceptable salt thereof, or combination thereof, in which X is H or alkyl group; Y is carbonyl group bonded to substituted/unsubstituted homo/hetero cyclic ring with at least one double bond or carboxyl group bonded to alkyl group; Z is carbonyl/carboxyl group bonded to substituted/unsubstituted homo/hetero cyclic ring with at least one double bond or alkene or o-alkyl substituted carbamate or carbonyl group bonded to branched alkyl group and W is H or amide group or carbonyl group bonded to branched alkyl group.