公开(公告)号：US08975300B2

公开(公告)日：2015-03-10

申请号：US14100547

申请日：2013-12-09

Applicant: Esperion Therapeutics, Inc.

Inventor： Jean-Louis Henri Dasseux ,  Carmen Daniela Oniciu

IPC: A61K31/19 ,  C07C59/353 ,  C07C49/17 ,  C07C49/185 ,  C07C49/215 ,  C07C49/245 ,  C07C49/258 ,  C07C49/507 ,  C07C49/723 ,  C07C49/743 ,  C07C49/747 ,  C07C49/784 ,  C07C49/82 ,  C07C49/86 ,  C07C50/30 ,  C07C59/347 ,  C07C59/82 ,  C07C59/84 ,  C07C59/90 ,  C07C69/716 ,  C07C69/738 ,  C07C235/74 ,  C07C261/04 ,  C07C309/07 ,  C07C309/24 ,  C07D233/72 ,  C07D233/84 ,  C07D233/86 ,  C07D257/04 ,  C07D261/12 ,  C07D305/12 ,  C07D307/33 ,  C07D309/12 ,  C07D309/30 ,  C07D309/40 ,  C07F9/09 ,  C07F9/24 ,  C07F9/44

CPC classification number: C07C59/353 ,  C07C49/17 ,  C07C49/185 ,  C07C49/215 ,  C07C49/245 ,  C07C49/258 ,  C07C49/507 ,  C07C49/723 ,  C07C49/743 ,  C07C49/747 ,  C07C49/784 ,  C07C49/82 ,  C07C49/86 ,  C07C50/30 ,  C07C59/347 ,  C07C59/82 ,  C07C59/84 ,  C07C59/90 ,  C07C69/716 ,  C07C69/738 ,  C07C235/74 ,  C07C261/04 ,  C07C309/07 ,  C07C309/24 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07D233/72 ,  C07D233/84 ,  C07D233/86 ,  C07D257/04 ,  C07D261/12 ,  C07D305/12 ,  C07D307/33 ,  C07D309/12 ,  C07D309/30 ,  C07D309/40 ,  C07F9/093 ,  C07F9/2425 ,  C07F9/4423

Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Abstract translation: 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

公开(公告)号：US20050176818A1

公开(公告)日：2005-08-11

申请号：US11105807

申请日：2005-04-13

Applicant: Gary Maupin ,  Joseph Karchesy ,  Nicholas Panella ,  Marc Dolan

Inventor： Gary Maupin ,  Joseph Karchesy ,  Nicholas Panella ,  Marc Dolan

IPC: A01N27/00 ,  A01N31/04 ,  A01N31/06 ,  A01N43/20 ,  C07C33/14 ,  C07C45/28 ,  C07C45/78 ,  C07C47/225 ,  C07C47/267 ,  C07C47/46 ,  C07C47/47 ,  C07C49/21 ,  C07C49/242 ,  C07C49/258 ,  C07C49/583 ,  C07C49/733 ,  C07C49/757 ,  C07D303/04 ,  C07D303/32 ,  A01N43/56 ,  A01N43/24

CPC classification number: C07D303/32 ,  A01N27/00 ,  A01N31/04 ,  A01N31/06 ,  A01N43/20 ,  C07C33/14 ,  C07C45/28 ,  C07C45/78 ,  C07C47/225 ,  C07C47/267 ,  C07C47/46 ,  C07C47/47 ,  C07C49/21 ,  C07C49/242 ,  C07C49/258 ,  C07C49/583 ,  C07C49/733 ,  C07C49/757 ,  C07D303/04 ,  Y02A40/166

Abstract: Compounds, compositions, and methods for controlling an arthropod pest population that employ an eremophilane sesquiterpene parent structure are presented. The compounds have minimal adverse or toxic effects on humans, non-human animals, and the natural environment. The compounds may be isolated from natural sources, semi-synthesized from naturally occurring compounds, or completely synthesized. The compounds may be applied directly to a pest, or the locus of a pest, and function as topical or ingestible toxins. Eremophilane sesquiterpenes 13-hydroxy-valencene, valencene-11,12-epoxide, valencene-13-aldehyde, and nootkatone-1,10-11,12-diepoxide are exemplary compounds.

Abstract translation: 提出了用于控制采用间苯二甲苯倍半萜母体结构的节肢动物种群的化合物，组合物和方法。 这些化合物对人类，非人类动物和自然环境具有最小的不利或毒性​​作用。 这些化合物可以从天然来源中分离，由天然存在的化合物半合成或完全合成。 化合物可以直接施用于有害生物或有害生物的场所，并且作为局部或摄入的毒素起作用。 间二甲苯基倍半萜烯13-羟基 - 戊烯，戊烯-1 11,12-环氧化物，戊烯-13-醛和诺塔卡酮-1,10-11,12-二环氧化物是示例性化合物。

公开(公告)号：US4827004A

公开(公告)日：1989-05-02

申请号：US88315

申请日：1987-08-24

Applicant: Albert Fischli ,  Max Schmid ,  Rudolf Schmid

Inventor： Albert Fischli ,  Max Schmid ,  Rudolf Schmid

IPC: A61K31/045 ,  A61K31/12 ,  A61K31/15 ,  A61K31/16 ,  A61K31/215 ,  A61K31/695 ,  A61P1/04 ,  C07C27/00 ,  C07C29/147 ,  C07C33/02 ,  C07C33/035 ,  C07C33/12 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C43/30 ,  C07C43/315 ,  C07C45/00 ,  C07C45/29 ,  C07C45/67 ,  C07C47/263 ,  C07C49/20 ,  C07C49/24 ,  C07C49/242 ,  C07C49/255 ,  C07C49/258 ,  C07C59/42 ,  C07C59/58 ,  C07C59/76 ,  C07C67/00 ,  C07C69/66 ,  C07C69/732 ,  C07C231/00 ,  C07C231/12 ,  C07C233/09 ,  C07C235/28 ,  C07C235/30 ,  C07C235/76 ,  C07C235/78 ,  C07C251/34 ,  C07C313/00 ,  C07C317/24 ,  C07C317/28 ,  C07C317/44 ,  C07C317/46 ,  C07C323/22 ,  C07C323/24 ,  C07C323/25 ,  C07C323/27 ,  C07C323/52 ,  C07C323/54 ,  C07C323/60 ,  C07C325/00 ,  C07C327/22 ,  C07D303/46 ,  C07D317/20 ,  C07D317/30 ,  C07F7/18 ,  C09F5/00

CPC classification number: C07F7/1852 ,  C07C323/00 ,  C07C323/24 ,  C07C33/02 ,  C07C33/035 ,  C07C33/12 ,  C07C43/178 ,  C07C43/315 ,  C07C45/298 ,  C07C45/673 ,  C07C47/263 ,  C07C49/24 ,  C07C49/242 ,  C07C49/255 ,  C07C49/258 ,  C07C59/42 ,  C07C59/76 ,  C07D317/20

Abstract: Novel Isoprene Derivatives which have mucosa-protective and gastric acid secretion-inhibiting properties and are useful for combatting ulcers both by treating and as a prophylaxis against gastric and/or duodenal ulcers.

Abstract translation: 具有粘膜保护性和胃酸分泌抑制性质的新型异戊二烯衍生物，可用于通过治疗和预防胃和/或十二指肠溃疡来对抗溃疡。

公开(公告)号：US4449007A

公开(公告)日：1984-05-15

申请号：US441221

申请日：1982-11-12

Applicant: John B. Hall ,  Mark A. Sprecker

Inventor： John B. Hall ,  Mark A. Sprecker

IPC: C07C45/45 ,  C07C49/175 ,  C07C49/185 ,  C07C49/255 ,  C07C49/258 ,  C07C49/303 ,  C07C49/355 ,  C07C49/557 ,  C07C49/583 ,  C07C51/02 ,  C07C59/80 ,  C07C69/716 ,  C07C403/00 ,  C11B9/00 ,  C07C45/67

CPC classification number: C11B9/0034 ,  C07C403/16 ,  C07C45/455 ,  C07C49/303 ,  C07C49/355 ,  C07C49/557 ,  C07C49/583 ,  C07C51/02 ,  C07C59/80 ,  C07C2101/14

Abstract: A process comprising the steps of reacting 1-acetyl-3,3-dimethylcyclohexane with an alkyl acetate, thereby forming a diketone having the structure: ##STR1## reacting the said diketone with an allyl halide to form a substituted diketone having the structure: ##STR2## which is transformed into the compound having the structure: ##STR3## by means of a retro-Claisen reaction. Also described is the use in augmenting or enhancing the aroma of perfume compositions, colognes or perfumed articles of the compound having the structure: ##STR4##

Abstract translation: 一种方法包括以下步骤：使1-乙酰基-3,3-二甲基环己烷与乙酸烷基酯反应，从而形成具有以下结构的二酮：将所述二酮与烯丙基卤反应形成具有以下结构的取代二酮： IMAGE“，其通过复古克莱森反应转化为具有以下结构的化合物：。 还描述了用于增强或增强具有以下结构的化合物的香料组合物，古龙水或香料制品的香味：

公开(公告)号：US4372881A

公开(公告)日：1983-02-08

申请号：US306827

申请日：1981-09-29

Applicant: Gunther Ohloff ,  Wolfgang K. Giersch

Inventor： Gunther Ohloff ,  Wolfgang K. Giersch

IPC: C07C45/40 ,  C07C45/60 ,  C07C45/68 ,  C07C49/258 ,  C07C49/557 ,  C11B9/00 ,  C07C45/66 ,  A61K7/46

CPC classification number: C11B9/0034 ,  C07C45/40 ,  C07C45/60 ,  C07C45/68 ,  C07C49/258 ,  C07C49/557

Abstract: Unsaturated alicyclic compounds of formula ##STR1## having a methyl radical bound to the carbon atom in position 5 or 6 of the ring, possess interesting perfuming and flavoring properties and consequently they can be used advantageously in the fragrance and flavor industry. They can develop various notes of green, flowery, fruity and fresh type.

Abstract translation: 具有与环的5或6位上的碳原子键合的甲基的式（I）的不饱和脂环化合物具有有趣的加香和调味特性，因此它们可以有利地用于香料和香料工业中。 他们可以开发各种各样的绿色，华丽，果味和新鲜的香味。

公开(公告)号：US3931270A

公开(公告)日：1976-01-06

申请号：US539092

申请日：1975-01-07

Applicant: William J. Evers ,  Bernard J. Mayers

Inventor： William J. Evers ,  Bernard J. Mayers

IPC: A23L27/20 ,  C07C49/203 ,  C07C49/258 ,  C07C327/20 ,  C07D307/64 ,  C07C153/07

CPC classification number: C07D307/64 ,  A23L27/2022 ,  A23L27/204 ,  C07C323/00 ,  C07C327/00 ,  C07C49/203 ,  C07C49/258

Abstract: Process for producing 3-thia substituted alkane 1,4 diones comprising the steps of:I. Providing a 2-ene-1,4 dione having the structure: ##SPC1##Ii. Intimately admixing said 2-ene-1,4 dione with a sulfur compound having the formula:R.sub.3 SH thereby providing a substituted or sunsubstituted 2-thia substituted alkane 1,4 dione having the structure: ##SPC2##WhereinR.sub.3 is selected from the group consisting of acyl and royl, wherein R.sub.2 is lower alkyl; and wherein R.sub.1, R.sub.4 and r.sub.6 are the same or different and are selected from the group consisting of hydrogen and lower alkyl; wherein when R.sub.1 is hydrogen, the reaction (ii) is carried out in the presence of an organic base; and wherein when R.sub.1 is lower alkyl, the reaction (ii) is carried out in the absence of catalyst. Examples of such organic bases are piperidine, pyridine, triethyl amine, quinoline or alpha-picoline.

Abstract translation: 制备3-硫杂取代的烷烃1,4二酮的方法，包括以下步骤：

公开(公告)号：US3824291A

公开(公告)日：1974-07-16

申请号：US11897171

申请日：1971-02-25

Applicant: HOFFMANN LA ROCHE

Inventor： PAWSON B ,  SAUCY G

IPC: C07C45/00 ,  C07C45/28 ,  C07C45/29 ,  C07C45/45 ,  C07C45/58 ,  C07C45/60 ,  C07C45/64 ,  C07C45/65 ,  C07C45/79 ,  C07C45/85 ,  C07C47/45 ,  C07C47/46 ,  C07C49/21 ,  C07C49/242 ,  C07C49/258 ,  C07C49/647 ,  C07C205/43 ,  C07C409/14 ,  C07D303/32 ,  C07D303/36 ,  C07D317/12 ,  C07D317/20 ,  C07D317/30 ,  C07D319/06 ,  C07C47/42

CPC classification number: C07D319/06 ,  C07B2200/07 ,  C07C47/46 ,  C07C2601/16 ,  C07D303/32 ,  C07D303/36 ,  C07D317/12 ,  C07D317/20 ,  C07D317/30

Abstract: THIS INVENTION IS DIRECTED TO A METHOD OF SYNTHESIZING JUVABIONE AND NOVEL DERIVATIVES THEREOF WHICH ARE USEFUL IN KILLING AND PREVENTING PROLIFERATION OF INSECTS BY UPSETTING THEIR HORMONE BALANCE INCLUDING INTERMEDIATES IN THIS PROCESS.

公开(公告)号：US3804883A

公开(公告)日：1974-04-16

申请号：US20110971

申请日：1971-11-22

Applicant: SANDOZ AG

Inventor： GALANTAY E

IPC: C07C39/19 ,  C07C45/29 ,  C07C45/30 ,  C07C45/67 ,  C07C45/71 ,  C07C45/72 ,  C07C47/56 ,  C07C47/575 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07F7/18 ,  C07C69/76

CPC classification number: C07F7/1852 ,  C07C39/19 ,  C07C45/29 ,  C07C45/292 ,  C07C45/30 ,  C07C45/673 ,  C07C45/71 ,  C07C45/72 ,  C07C69/734 ,  C07C49/258 ,  C07C47/575 ,  C07C47/56 ,  C07C49/248 ,  C07C49/255

Abstract: THE INVENTION DISCLOSED COMPOUNDS OF THE FORMULA:

1-(Q-(CH2)5-),2-(R0-X-CH=CH-),3,5-DI(R-O-)BENZENE

IN WHICH X IS -CHOH- OR -CO-; Q IS -CH2OH, -COOR'' OR, IN CERTAIN INSTANCES, -CHO OR

-CH2OOCR"

R* IS STRAIGHT CHAIN LOWER ALKYL (C4-C6); AND R IS HYDROGEN, ALKYL CYCLOALKYL OR -OCR"; R'' IS HYDROGEN (OR A SUBSTITUTE SALT FORMING CATION) OR R"; AND R" IS ALKYL, AS DIFINED OR QUALIFIED IN THE FOLLOWNG SPECIFICATION, E.G. 1(2''4''-DIMETHOXY-6''-W-HYDROXYETHYL-1''-PHENYL) - 1 -OCTEN3-ONE, SAID COMPOUNDS BEING USEFUL AS PHARMACEUTICAL AGENTS, E.G. AS AGENTS FOR CONTROL OF REPRODUCTION INFE FEMALES. THE ABOVE FINAL PRODUCTS AMY BE PREPARED BY REACTING A 6-W-SUBSTITUTED-HEXYL-,4-DISUBSTITUTED - BENZALDEHYDE WITH A DIALKYL-2-OXOALKYL PHOSPHORANE IN THE PRESENCE OF THE BASE OR FROM CERTAIN OF THE FINAL PRODUCTS BY OXIDATION, ESTERFICATION OR REDUCTION DEPENDING ON THE FINAL PRODUCT DESIRED. THE 6-W-SUBSTITUTED-HEXYL - 2,3-DISUBSTITUTED-BENZALDEHYDES ARE OBTAINED BY BENZYLIC OXIDATION OF A 4-HYDROXYMETHYL-5-W-HYDROXYLHEXYL-1,3-DISUBSTITUTED-BENZENE WHICH IN TURN ARE OBTAINED BY REDUCTION OF A 6-2-CARBOXYPENTYL-2,4-DISUBSTITUTED-BENZOIC ACID.

公开(公告)号：US3705919A

公开(公告)日：1972-12-12

申请号：US3705919D

申请日：1971-02-08

Applicant: HERCULES INC

Inventor： HECK RICHARD F

IPC: C07B61/00 ,  C07C1/32 ,  C07C2/86 ,  C07C17/26 ,  C07C45/00 ,  C07C45/51 ,  C07C45/54 ,  C07C45/68 ,  C07C45/69 ,  C07C47/232 ,  C07C49/215 ,  C07C49/258 ,  C07C49/657 ,  C07C49/782 ,  C07C49/84 ,  C07C51/09 ,  C07C51/363 ,  C07C59/90 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/56 ,  C07C209/68 ,  C07D333/08 ,  C07D333/12 ,  C07D333/24 ,  C07F3/10 ,  C07F3/12 ,  C07C67/00

CPC classification number: C07F3/12 ,  C07C1/325 ,  C07C2/86 ,  C07C2/862 ,  C07C17/263 ,  C07C45/00 ,  C07C45/512 ,  C07C45/54 ,  C07C45/68 ,  C07C51/09 ,  C07C51/363 ,  C07C59/90 ,  C07C201/12 ,  C07C209/68 ,  C07C255/00 ,  C07D333/08 ,  C07D333/12 ,  C07D333/24 ,  C07C15/44 ,  C07C22/04 ,  C07C23/28 ,  C07C47/232 ,  C07C49/657 ,  C07C49/213 ,  C07C49/782 ,  C07C49/84 ,  C07C49/215 ,  C07C49/217 ,  C07C47/225 ,  C07C57/60 ,  C07C63/64 ,  C07C63/70 ,  C07C205/06 ,  C07C205/11 ,  C07C205/56 ,  C07C205/35 ,  C07C205/45

Abstract: USEFUL ORGANIC COMPOUNDS ARE PRODUCED BY CONTACTING AN ETHYLENICALLY UNSATURATED ORGANIC COMPOUND WITH AN ORGANOMETALLIC COMPOUND OF A GROUP VIII METAL HAVING AN ATOMIC NUMBER IN THE RANGE OF 44-78 IN THE PRESENCE OR ABSENCE OF A CUPRIC SALT, AND THE ORGANIC COMPOUNDS PRODUCED ARE CONDENSATION PRODUCTS OF TE ORGANO GROUP WITH THE UNSATURATED ORGANIC COMPOUND.

公开(公告)号：US20170342029A1

公开(公告)日：2017-11-30

申请号：US15533202

申请日：2015-12-07

Applicant: ADISSEO FRANCE S.A.S.

Inventor： Patrick REY ,  Virginie BELLIERE-BACA ,  Franck DUMEIGNIL ,  Fabien GRASSET

IPC: C07C319/18 ,  B01J23/00 ,  C07C51/23 ,  C07C49/258 ,  C07C49/24 ,  C07C45/39 ,  C07C59/76 ,  B01J23/44 ,  B01J27/185 ,  B01J37/02 ,  B01J37/08 ,  C07C323/54 ,  B01J23/96 ,  B01J27/28 ,  B01J37/16 ,  B01J38/02 ,  B01J38/48

CPC classification number: C07C319/18 ,  B01J23/007 ,  B01J23/44 ,  B01J23/96 ,  B01J27/1856 ,  B01J27/285 ,  B01J37/0201 ,  B01J37/088 ,  B01J37/16 ,  B01J38/02 ,  B01J38/48 ,  B01J2523/00 ,  C07C45/37 ,  C07C45/39 ,  C07C51/23 ,  Y02P20/584 ,  C07C49/24 ,  C07C49/258 ,  C07C59/76 ,  C07C323/52 ,  C07C323/22 ,  B01J2523/23 ,  B01J2523/51 ,  B01J2523/824 ,  B01J2523/828 ,  B01J2523/22 ,  B01J2523/31

Abstract: The invention concerns a synthesis process of a compound of the following formula (I) or one of the salts thereof, wherein R represents a COOH, CH2OH or CHO group, comprising the step according to which the but-3-ene-1,2-diol (BDO) is subjected to an oxidation in the presence of a catalyst, said catalyst comprising an active phase based on at least one noble metal selected from palladium, gold, silver, platinum, rhodium, osmium, ruthenium and iridium, and a support containing alkaline sites. The invention also concerns the application of this reaction to the preparation of bioavailable compounds of methionine used, in particular, in animal nutrition.