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公开(公告)号：US20200282103A1
公开(公告)日：2020-09-10
申请号：US16651431
申请日：2018-10-01
申请人： Polyganics IP B.V.
IPC分类号： A61L24/04
摘要： The invention is directed to a multi-arm tissue-adhesive polymer wherein at least six or more arms each comprise a reactive functional group that can form a urethane or a urea bond with an amine group present in tissue, as well as to the use thereof for sealing or closing of tissue and use in a medical treatment of a human or animal body. In a further aspect, the invention is directed to a method for the preparation of said multi-arm tissue-adhesive polymer.
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公开(公告)号：US20200254137A1
公开(公告)日：2020-08-13
申请号：US16089610
申请日：2017-03-31
申请人： Polyganics IP B.V.
摘要： The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.
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公开(公告)号：US20220185958A1
公开(公告)日：2022-06-16
申请号：US17437600
申请日：2020-03-11
申请人： Polyganics IP B.V.
发明人： Martin Franke Tooren
IPC分类号： C08G65/333 , C08G69/16 , A61L24/04 , A61L24/00
摘要： The invention is directed to a tissue-adhesive multi-arm polymer comprising a core from which polymeric arms extent, which polymeric arms are substituted with a hydroxyl-substituted aromatic group based on compounds such as dopamine, L-DOPA, D-DOPA, tyramine, noradrenaline and/or serotonin. In addition, the invention is directed to a caprolactam blocked hydroxyl-substituted aromatic compound, suitable for the preparation of the tissue-adhesive multi-arm polymer and to the method for the preparation of the tissue-adhesive multi-arm polymer.
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公开(公告)号：US20190231935A1
公开(公告)日：2019-08-01
申请号：US16382652
申请日：2019-04-12
申请人： Polyganics IP B.V.
CPC分类号： A61L27/56 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2420/08
摘要： The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.
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公开(公告)号：US20180028725A1
公开(公告)日：2018-02-01
申请号：US15553201
申请日：2016-02-29
申请人： Polyganics IP B.V.
CPC分类号： A61L27/56 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2420/08
摘要： The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.
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公开(公告)号：US11633517B2
公开(公告)日：2023-04-25
申请号：US16089582
申请日：2017-03-31
申请人： Polyganics IP B.V.
IPC分类号： A61L27/18 , A61L27/50 , A61L27/58 , A61L27/60 , C08G18/73 , C08G18/42 , C08G18/44 , C08G18/75 , C08G18/77 , C08G18/24 , C08J9/28 , C08L75/06 , C08G18/10 , C08G18/32
摘要： The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.
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公开(公告)号：US11129920B2
公开(公告)日：2021-09-28
申请号：US16089610
申请日：2017-03-31
申请人： Polyganics IP B.V.
IPC分类号： C09J175/06 , A61L24/04 , C08G18/34 , A61L24/00 , A61L31/06 , A61L31/14 , C08G18/10 , C08G18/73
摘要： The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.
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公开(公告)号：US20190099518A1
公开(公告)日：2019-04-04
申请号：US16089582
申请日：2017-03-31
申请人： Polyganics IP B.V.
摘要： The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.
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公开(公告)号：US20230302194A1
公开(公告)日：2023-09-28
申请号：US18188571
申请日：2023-03-23
申请人： Polyganics IP B.V.
CPC分类号： A61L27/18 , A61L27/507 , A61L27/58 , A61L27/60 , C08G18/42 , C08G18/73 , A61L2430/06 , A61L2430/32
摘要： The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.
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公开(公告)号：US20230056537A1
公开(公告)日：2023-02-23
申请号：US18046551
申请日：2022-10-14
申请人： Polyganics IP B.V.
摘要： The invention is directed to a multilayered drug eluting biodegradable foam comprising at least two layers, wherein each layer independently comprises a polymer and wherein at least one of said layers is a drug-comprising layer, which comprises at least one drug that is mixed with the polymer in said drug-comprising layer.
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