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公开(公告)号:US20090286793A1
公开(公告)日:2009-11-19
申请号:US12506222
申请日:2009-07-20
申请人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
发明人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号: A61K31/4365 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P11/00 , A61P25/00 , A61P35/00 , A61P19/00
CPC分类号: C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
摘要翻译: 提供了磷酸二酯酶PDE4B活性的化合物。 本文还提供了可用于治疗PDE4B介导的疾病或病症的组合物及其使用方法。
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公开(公告)号:US07585859B2
公开(公告)日:2009-09-08
申请号:US11123893
申请日:2005-05-06
申请人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
发明人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号: A61K31/5377 , A61K31/4525 , A61K31/422 , C07D413/14 , C07D409/14 , C07D261/06
CPC分类号: C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
摘要翻译: 提供了磷酸二酯酶PDE4B活性的化合物。 本文还提供了可用于治疗PDE4B介导的疾病或病症的组合物及其使用方法。
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公开(公告)号:US08470821B2
公开(公告)日:2013-06-25
申请号:US12506222
申请日:2009-07-20
申请人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
发明人: Prabha N. Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean R. Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号: A61K31/5377 , A61K31/4365 , C07D471/04 , C07D413/14
CPC分类号: C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
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公开(公告)号:US07605168B2
公开(公告)日:2009-10-20
申请号:US11219635
申请日:2005-09-02
申请人: Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
发明人: Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
IPC分类号: A61K31/437 , A61K31/403 , C07D471/02 , C07D405/02
CPC分类号: C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译: 描述了在PDE4上有活性的化合物。 还描述了使用X射线晶体学测定的PDE4B的晶体结构,使用PDE4B晶体和用于鉴定分子支架的结构信息,用于开发结合和调节PDE4B的配体,以及基于已知配体鉴定改进的配体。
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公开(公告)号:US08415469B2
公开(公告)日:2013-04-09
申请号:US12616079
申请日:2009-11-10
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号: C07D413/14 , C07D401/14 , C07D471/04 , C07F7/02
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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6.
公开(公告)号:US20120053177A1
公开(公告)日:2012-03-01
申请号:US13243748
申请日:2011-09-23
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号: A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译: 描述了对蛋白激酶有活性的化合物,以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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公开(公告)号:US20100256365A1
公开(公告)日:2010-10-07
申请号:US12616079
申请日:2009-11-10
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号: C07D413/14 , C07D401/14 , C07F7/02 , C07D471/04
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号:US20060041006A1
公开(公告)日:2006-02-23
申请号:US11123893
申请日:2005-05-06
申请人: Prabha Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean Artis , Rebecca Zuckerman , Chao Zhang
发明人: Prabha Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号: A61K31/4025 , A61K31/401 , A61K31/381 , A61K31/34 , C07D409/02 , C07D403/02
CPC分类号: C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
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公开(公告)号:US08143271B2
公开(公告)日:2012-03-27
申请号:US13216200
申请日:2011-08-23
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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10.
公开(公告)号:US08470818B2
公开(公告)日:2013-06-25
申请号:US12906980
申请日:2010-10-18
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi
IPC分类号: A61K31/535
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译: 描述了对蛋白激酶有活性的化合物,以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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