公开(公告)号：US20150132742A1

公开(公告)日：2015-05-14

申请号：US14404120

申请日：2013-06-03

申请人： President and Fellows of Harvard College

发明人： Martin Mwangi Thuo ,  Ramses V. Martinez ,  Ana C. Glavan ,  Wenjie Lan ,  Xinyu Liu ,  Jean-Francis Bloch ,  George M. Whitesides

IPC分类号： B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/502738 ,  B01L3/502784 ,  B01L3/5085 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/126 ,  B01L2300/165 ,  Y10T436/143333

摘要： Microfluidic devices fabricated from paper that has been covalently modified to increase its hydrophobicity, as well as methods of making and using thereof are provided herein. The devices are typically small, portable, flexible, and both easy and inexpensive to fabricate. Microfluidic devices contain a network of microfluidic components, including microfluidic channels, microfluidic chambers, microwells, or combinations thereof, designed to carry, store, mix, react, and/or analyze liquid samples. The microfluidic channels may be open channels, closed channels, or combinations thereof. The microfluidic devices may be used to detect and/or quantify an analyte, such as a small molecules, proteins, lipids polysaccharides, nucleic acids, prokaryotic cells, eukaryotic cells, particles, viruses, metal ions, and combinations thereof.

摘要翻译： 本文提供了由共价修饰以增加其疏水性的纸制造的微流体装置，以及其制备和使用方法。 这些设备通常是小型，便携式的，灵活的，并且既便宜又便宜地制造。 微流体装置包含设计用于携带，储存，混合，反应和/或分析液体样品的微流体组分的网络，包括微流体通道，微流体室，微孔或其组合。 微流体通道可以是开放通道，闭合通道或其组合。 微流体装置可用于检测和/或定量分析物，例如小分子，蛋白质，脂质多糖，核酸，原核细胞，真核细胞，颗粒，病毒，金属离子及其组合。

公开(公告)号：US09992867B2

公开(公告)日：2018-06-05

申请号：US15301501

申请日：2015-04-13

申请人： President and Fellows of Harvard College

发明人： Joshua Aaron Lessing ,  Ana C. Glavan ,  S. Brett Walker ,  Christoph Matthias Keplinger ,  George M. Whitesides

IPC分类号： H05K1/00 ,  H05K1/03 ,  B41M5/52 ,  D21H21/16

CPC分类号： H05K1/0386 ,  B41M5/52 ,  B41M5/529 ,  D21H17/11 ,  D21H17/13 ,  D21H21/00 ,  D21H21/16 ,  D21H27/00 ,  H05K1/181 ,  H05K3/1208

摘要： A cellulosic substrate-based device is described, including a cellulosic substrate comprising a functionalized surface covalently functionalized by a chemical moiety in an amount sufficient to provide an omniphobic or hydrophobic surface; and a material printed on the functionalized surface, wherein the printed material has a line edge roughness of less than about 15 μm and/or a line lateral resolution of less than about 50 μm.