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Patent Agency Ranking
公开(公告)号：US20180327702A1
公开(公告)日：2018-11-15
申请号：US15777242
申请日：2016-11-18
Applicant: President and Fellows of Harvard College
Inventor： Alanna R. Gannon , Aaron L. Glieberman , Kevin Kit Parker , Benjamin D. Pope , Kevin L. Shores , Nina R. Sinatra
CPC classification number: C12M23/42 , C12M21/08 , C12Q1/00 , C40B40/10 , G01N33/5023 , G01N33/507 , G01N33/5082
Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.
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公开(公告)号：US20230287318A1
公开(公告)日：2023-09-14
申请号：US18116863
申请日：2023-03-03
Applicant: President and Fellows of Harvard College
Inventor： Benjamin D. Pope , Kevin Kit Parker
CPC classification number: C12M21/08 , A61K35/28 , C12M23/20 , C12M25/00 , C12N5/0653 , C12N2533/30 , C12N2533/90 , C12N2535/00
Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
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公开(公告)号：US11384328B2
公开(公告)日：2022-07-12
申请号：US15777242
申请日：2016-11-18
Applicant: President and Fellows of Harvard College
Inventor： Alanna R. Gannon , Aaron L. Glieberman , Kevin Kit Parker , Benjamin D. Pope , Kevin L. Shores , Nina R. Sinatra
Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.
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公开(公告)号：US20200248116A1
公开(公告)日：2020-08-06
申请号：US16757133
申请日：2018-10-19
Applicant: President and Fellows of Harvard College
Inventor： Benjamin D. Pope , Kevin Kit Parker
Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
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公开(公告)号：US11629318B2
公开(公告)日：2023-04-18
申请号：US16757133
申请日：2018-10-19
Applicant: President and Fellows of Harvard College
Inventor： Benjamin D. Pope , Kevin Kit Parker
Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
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