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公开(公告)号：US10435457B2
公开(公告)日：2019-10-08
申请号：US15750788
申请日：2016-08-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander Watters , Brendon Dusel , Michael Super , Mark Cartwright , Donald E. Ingber
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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Patent Agency Ranking
公开(公告)号：US11807677B2
公开(公告)日：2023-11-07
申请号：US17552662
申请日：2021-12-16
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander Watters , Brendon Dusel , Michael Super , Mark Cartwright , Donald E. Ingber
CPC classification number: C07K14/78 , C07K14/00 , C07K14/4726 , C07K19/00 , G01N33/569 , A61K38/00 , C07K2319/30 , G01N2333/78 , G01N2400/00
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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公开(公告)号：US10813988B2
公开(公告)日：2020-10-27
申请号：US15434781
申请日：2017-02-16
Applicant: President and Fellows of Harvard College
Inventor： Michael Super , Edward J. Doherty , Mark Cartwright , Des White , Alexander G. Stafford , Omar Abdel-Rahman Ali , Amanda Graveline , Donald E. Ingber , David J. Mooney , Benjamin Seiler
IPC: A61K39/108 , A61K39/02 , A61K39/00
Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
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公开(公告)号：US20170246281A1
公开(公告)日：2017-08-31
申请号：US15434781
申请日：2017-02-16
Applicant: President and Fellows of Harvard College
Inventor： Michael Super , Edward J. Doherty , Mark Cartwright , Des White , Alexander G. Stafford , Omar Abdel-Rahman Ali , Amanda Graveline , Donald E. Ingber , David J. Mooney , Benjamin Seiler
IPC: A61K39/108 , A61K39/02
Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
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公开(公告)号：US11236149B2
公开(公告)日：2022-02-01
申请号：US16879015
申请日：2020-05-20
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander Watters , Brendon Dusel , Michael Super , Mark Cartwright , Donald E. Ingber
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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公开(公告)号：US10696733B2
公开(公告)日：2020-06-30
申请号：US16553635
申请日：2019-08-28
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander Watters , Brendon Dusel , Michael Super , Mark Cartwright , Donald E. Ingber
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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