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1.发明申请MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 有权用于生产4-羟基丁酸酯，1,4-丁二醇和相关化合物的微生物和方法公开(公告)号：US20140030779A1
公开(公告)日：2014-01-30
申请号：US13908907
申请日：2013-06-03
申请人： Priti PHARKYA , Anthony P. BURGARD , Stephen J. VAN DIEN , Robin E. OSTERHOUT , Mark J. BURK , John D. TRAWICK , Michael P. KUCHINSKAS , Brian STEER
发明人： Priti PHARKYA , Anthony P. BURGARD , Stephen J. VAN DIEN , Robin E. OSTERHOUT , Mark J. BURK , John D. TRAWICK , Michael P. KUCHINSKAS , Brian STEER
CPC分类号： C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.
摘要翻译： 本发明提供具有4-羟基丁酸途径并且能够产生4-羟基丁酸酯的非天然存在的微生物生物，其中微生物生物体包含一种或多种遗传修饰。 本发明另外提供了使用微生物生物制备4-羟基丁酸酯或相关产品的方法。
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2.发明申请MICROORGANISMS AND METHODS FOR THE PRODUCTION OF 1,4-CYCLOHEXANEDIMETHANOL 审中-公开用于生产1,4-环己烷二甲醇的微生物和方法公开(公告)号：US20120156740A1
公开(公告)日：2012-06-21
申请号：US13327385
申请日：2011-12-15
申请人： Priti PHARKYA , Mark J. Burk
发明人： Priti PHARKYA , Mark J. Burk
CPC分类号： C12P7/02 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/76 , C12N15/78 , C12N15/81 , C12N15/815 , C12P7/18
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,4-cyclohexanedimethanol pathway that includes at least one exogenous nucleic acid encoding a 1,4-cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4-cyclohexanedimethanol. A method for producing 1,4-cyclohexanedimethanol includes culturing a non-naturally occurring microbial organism having a 1,4-cyclohexanedimethanol pathway. The pathway includes at least one exogenous nucleic acid encoding a 1,4-cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4-cyclohexanedimethanol, under conditions and for a sufficient period of time to produce 1,4-cyclohexanedimethanol.
摘要翻译： 非天然存在的微生物体包括具有1,4-环己烷二甲醇途径的微生物生物体，其包含至少一种编码1,4-环己烷二甲醇途径酶的外源核酸，其以足以产生1,4-环己烷二甲醇的量表达。 生产1,4-环己烷二甲醇的方法包括培养具有1,4-环己烷二甲醇途径的非天然存在的微生物。 该途径包括至少一种编码1,4-环己烷二甲醇途径酶的外源核酸，其在足以在足够的时间内产生1,4-环己烷二甲醇以足够量产生1,4-环己烷二甲醇。
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公开(公告)号：US20120309062A1
公开(公告)日：2012-12-06
申请号：US13525133
申请日：2012-06-15
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/10 , C12Y101/01035 , C12Y102/0101 , C12Y103/01031 , C12Y206/01 , C12Y402/01
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
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