公开(公告)号：US20230416707A1

公开(公告)日：2023-12-28

申请号：US18030291

申请日：2021-10-07

Applicant: Protalix Ltd.

Inventor： Ilya RUDERFER ,  Liat FUX ,  Yael HAYON

IPC: C12N9/22 ,  A61K47/60 ,  A61P1/00 ,  A61P7/00 ,  A61P31/04 ,  A61P9/10 ,  A61P31/12

CPC classification number: C12N9/22 ,  A61K47/60 ,  A61P1/00 ,  A61P7/00 ,  A61P31/04 ,  A61P9/10 ,  A61P31/12 ,  C12Y301/21001

Abstract: A modified DNase protein is described herein as well as pharmaceutical compositions comprising same, the modified DNase protein comprising a DNase polypeptide attached to at least two poly(alkylene glycol) moieties. Further described herein is a process of preparing a modified DNase protein, the process comprising: contacting the polypeptide with an agent that comprises a poly(alkylene glycol) attached to an aldehyde group, to obtain a conjugate of the polypeptide and the agent; and contacting the conjugate with a reducing agent.

公开(公告)号：US20220106578A1

公开(公告)日：2022-04-07

申请号：US17555557

申请日：2021-12-20

Applicant: Protalix Ltd.

Inventor： Lilach CHEN ZELTSBURG ,  Ilya RUDERFER ,  Avidor SHULMAN ,  Liat FUX ,  Yulia UGORTSEV ,  Hagit NETA ,  Sivan GELLEY ,  Elad LAVEE LAVIAD ,  Yoseph SHAALTIEL

IPC: C12N9/22 ,  C12N9/16 ,  A61K38/46 ,  A61P43/00 ,  A61P11/00

Abstract: Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.

公开(公告)号：US20180112201A1

公开(公告)日：2018-04-26

申请号：US15540264

申请日：2016-01-04

Applicant: Protalix Ltd.

Inventor： Lilach CHEN ZELTSBURG ,  Ilya RUDERFER ,  Avidor SHULMAN ,  Liat FUX ,  Yulia UGORTSEV ,  Hagit NETA ,  Sivan GELLEY ,  Elad LAVEE LAVIAD ,  Yoseph SHAALTIEL

IPC: C12N9/22 ,  A61P11/00 ,  A61P43/00

CPC classification number: C12N9/22 ,  A61K38/00 ,  A61P11/00 ,  A61P43/00 ,  C12N9/16

Abstract: Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.