公开(公告)号：US20230074255A1

公开(公告)日：2023-03-09

申请号：US17716348

申请日：2022-04-08

Applicant: Protalix Ltd.

Inventor： Avidor Shulman ,  Ilya Ruderfer ,  Tehila Ben-Moshe ,  Talia Shekhter ,  Yaniv Azulay ,  Tali Kizhner ,  Yoseph Shaaltiel

IPC: C12N9/40

Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

公开(公告)号：US09708595B2

公开(公告)日：2017-07-18

申请号：US14936720

申请日：2015-11-10

Applicant: Protalix Ltd.

Inventor： Avidor Shulman ,  Ilya Ruderfer ,  Tehila Ben Moshe ,  Talia Shekhter ,  Yaniv Azulay ,  Yoseph Shaaltiel ,  Tali Kizhner

IPC: A61K38/54 ,  C12N9/40 ,  C12N9/96 ,  C07H21/04 ,  C07K1/00 ,  A61K38/00

CPC classification number: C12N9/2465 ,  A61K38/00 ,  C12Y302/01022

Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

公开(公告)号：US20190256832A1

公开(公告)日：2019-08-22

申请号：US16356238

申请日：2019-03-18

Applicant: Protalix Ltd.

Inventor： Avidor Shulman ,  Ilya Ruderfer ,  Tehila Ben-Moshe ,  Talia Shekhter ,  Yaniv Azulay ,  Tali Kizhner ,  Yoseph Shaaltiel

IPC: C12N9/40

Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

公开(公告)号：US10280414B2

公开(公告)日：2019-05-07

申请号：US15636753

申请日：2017-06-29

Applicant: Protalix Ltd.

Inventor： Avidor Shulman ,  Ilya Ruderfer ,  Tehila Ben-Moshe ,  Talia Shekhter ,  Yaniv Azulay ,  Tali Kizhner ,  Yoseph Shaaltiel

IPC: C12N9/40 ,  A61K38/00

Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.